Authors:Alexey Tymoshenko, Gennadii Tkach, Vitalii Sikora, Valentina Bumeister, Ihor Shpetnyi, Mykola Lyndin, Olena Maksymova, and Anna Maslenko
effect on all biological species  . Direct or indirect intake of different contaminants can cause a disease or become a reason for the development of related disorders [2, 3] .
Heavy metals are considered to be terribly dangerous for their
Authors:Anatolii Romaniuk, Vladyslav Sikora, Mykola Lyndin, Vladyslav Smiyanov, Volodymyr Sikora, Yulia Lyndina, Artem Piddubnyi, Nataliya Gyryavenko, and Anna Korobchanska
into biosphere is comprised of heavy metal salts (HMS). The prevalence and toxicity of these metals pose a significant problem to many countries [ 3, 4 ]. Unfortunately, because of the increase in day-to-day pollution by various emissions, ecological
Authors:A. Bersényi, S. Gy. Fekete, Z. Szőcs, and Erzsébet Berta
Drasch, G., Wanghofer, E. and Roider, G. (1997): Are blood, urine, hair, and muscle valid biomonitors for the internal burden of men with the heavy metals mercury, lead and cadmium? Trace Elements and Electrolytes 14 , 116
Authors:Anatolii Romaniuk, Mykola Lyndin, Roman Moskalenko, Yevhen Kuzenko, Oksana Gladchenko, and Yuliia Lyndina
Materials and Methods: Chemical composition was studied with the help of the scanning electron microscope with energy-dispersion spectrometer. Immunohistochemical reaction showed the p53 and Ki-67 receptors expression. The study of DNA fragmentation was performed in agarose gel. Results: There was an interrelation between the accumulations of the trace elements with the degree of cancer malignancy. There were 85% of cases with positive reaction to Ki-67 and 40% cases with positive reaction to p53. We found a moderate correlation between the accumulation of microelements in the breast cancer tissue and the level of proliferative activity. We noted the combination of the increase of DNA fragmentation with the expression of p53 and Ki-67 receptors. Conclusions: The trace elements can cause the initiation and the progression of the tumorous growth, which is expressed in the increased proliferation of tumor cells. This leads to the destabilization of the genetic material which can be expressed in the synthesis of mutant p53 protein. Finally, it leads to the block of apoptosis and regulatory effects of cells. This can cause the tumor progression and the destabilization of the genome, which is reflected in the increased DNA fragmentation.
Authors:Maksym Pogorielov, Eugenia Husak, Alexandr Solodivnik, and Sergii Zhdanov
]. Compared with other materials, these metals have high impact strength, high wear resistance, high ductility, and toughness [ 2 ]. Hence, these metals are used in orthopedy, general, and cardiovascular surgeries because of their appropriate mechanical and