Authors:L. Costantini, R. Molinari, and N. Merendino
Some studies suggested a positive effect against cardiometabolic diseases of supplementation of alpha-linolenic acid (ALA, C18:3 n-3) rich foods in pathological subjects, even if the total literature is controversial. In order to clarify ALA-rich chia seed action in hypertensive model with the overt pathology and without drug interference, in the present study the biochemical markers of cardiometabolic diseases (endothelin-1, ET-1; nitric oxide, NO; and bradykinin, BK) in Spontaneously Hypertensive Rats (SHRs) were analysed after 5% chia seed dietary supplementation for five weeks, and compared with the staple raw material wheat and corn. At the end of the experimental period, also plasma antioxidant capacity and inflammatory condition were evaluated. Our results showed that the chia seed group was more oxidized. On the other hand, ET-1 significantly decreased in chia seed group, and there was no difference between groups for NO, BK, and the inflammatory C-reactive protein (CRP). In conclusion, some positive effects of chia seed consumption on cardiometabolic markers in SHRs were observed, despite this the association of chia seeds with antioxidants is suggested to avoid plasma oxidation increase.
Authors:Barhm Mohamad, Jalics Karoly, Andrei Zelentsov, and Salah Amroune
Sohn Verlag , 2007 , p. 1032 .  R. Z. Kavtaradze , D. O. Onishchenko , A. A. Zelentsov , and S. S. Sergeev , “ The influence of rotational charge motion intensity on nitricoxide formation in gas-engine cylinder ”, Int. J. Heat Mass
Authors:M. Gąsecka, M. Mleczek, M. Siwulski, P. Niedzielski, and L. Kozak
, J. , Zhang , M. , Lu , L. , Sun , L. & Xu , M ( 2012 ): Nitricoxide fumigation stimulates flavonoid and phenolic accumulation and enhances antioxidant activity of mushroom . Food Chem. , 135 , 1220 – 1225
Authors:H. Coutinho, J. Costa, V. Falcão-Silva, J. Siqueira-Júnior, and E. Lima
Wazlawik, E., Da Silva, M.A., Peters, R.R., Correia, J.F., Farias, M.R., Calixto, J.B. & Ribeiro-Do-Valle, R.M. (1997): Analysis of the role of nitricoxide in the relaxant effect of the crude extract and fractions from Eugenia uniflora in the rat