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augmentation for clozapine-treated patient with refractory schizophrenia”, Aug 2017; https://clinicaltrials.gov/ct2/show/NCT00328367. [4] “Effectiveness of aripiprazole for improving side effects of clozapine in the treatment

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The γ-amino butyric acid (GABA) is the main inhibitory neurotransmitter system in the brain. Either imbalance in the extreme can result in several mental diseases like schizophrenia, cerebral stroke, temporal lobe epilepsy (TLE), Parkinson’s disease (PD), Huntington’s disease (HD), and anxiety disorders even death. Measurement of GABA in tissue will help to elucidate the metabolic role and diagnostic value. Various analytical techniques are employed to estimate GABA in biological samples but the experimental procedure and tedious techniques are required. The present study demonstrates a simple, feasible, and cost-effective high-performance thinlayer chromatography (HPTLC) method for estimation of GABA in mice brain tissue. The method was validated in terms of specificity, linearity, and detection limit. The precision was done for inter-day, intra-day, instrumental, and reproducibility. Accuracy was checked by recovery study. The results indicate that this method is fast, sensitive, and suitable for quantitative assessment.

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Summary

Aripiprazole is a novel atypical antipsychotic drug used in the treatment of schizophrenia. The sensitive and reproducible ion pair RPLC method was developed and validated for determination of aripiprazole and its nine impurities, which are significantly different in polarity. The separation was performed on Phenomenex Luna® C18 column (5.0 μm particle size, 250 × 4.6 mm id) using a gradient mobile phase A (phosphate buffer pH 3.0) and mobile phase B (acetonitrile) at the working temperature of 25°C. The buffer was 1.11 g KH2PO4 with 1.2 g sodium pentanesulfonate/L of the solution, adjusted to pH 3.0 with orthophosphoric acid. The flow rate was 1.0 mL/min. The detection was carried out at 215 nm using a diode array detector. The developed method was validated according to the International Conference on Harmonization (ICH) guidelines for specificity, limit of detection, limit of quantification, linearity, precision and robustness. The proposed method is convenient and reliable for the purity control in both raw materials and dosage forms.

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Journal of Thermal Analysis and Calorimetry
Authors: K. L. G. V. Araújo, P. S. Epaminondas, M. C. D. Silva, A. E. A. de Lima, R. Rosenhaim, A. S. Maia, L. E. B. Soledade, A. L. Souza, I. M. G. Santos, A. G. Souza, and N. Queiroz

cardio protective effects are observed besides reduction in the risk of cancer, psoriasis, Parkinson’s disease, Alzheimer’s disease, schizophrenia, and joint problems [ 1 – 5 ]. However, the presence of long chain polyunsaturated fatty acids makes

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Journal of Thermal Analysis and Calorimetry
Authors: Marco Júnio Peres-Filho, Marilisa Pedroso Nogueira Gaeti, Stela Ramirez de Oliveira, Ricardo Neves Marreto, and Eliana Martins Lima

powder X-ray diffraction. OLZ is an atypical antipsychotic drug. Indications approved by the FDA include the monotherapy treatment of schizophrenia and bipolar mania [ 21 ]. OLZ has a distinctive market relevance, with sales reaching, according to the

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-amino acids were reported in human biological samples at some stages in certain neurological disorders [ 6 ]. In human tissues and biofluids, anomalous quantities of D-amino acids were accounted for their association with the diseases, like schizophrenia [ 7

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