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Interventional Medicine and Applied Science
Authors: Anand Maurya, Anurag Kumar Singh, Gaurav Mishra, Komal Kumari, Arati Rai, Bhupesh Sharma, Giriraj T. Kulkarni, and Rajendra Awasthi

improved oral bioavailability (5.6-fold) and half-life of curcumin compared with that of pure curcumin. The improved oral bioavailability of curcumin might be associated with improved solubility due to the increased effective surface area of NPs [ 23

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Abstract

The aim of the study was to compare the efficacy of pulmonary vein antrum isolation (PVAI), extended PVAI and ganglionic plexi (GP) ablation in persistent AF.

Methods

One hundred and twenty patients 56.2 ± 8.8 years old were randomized into three groups: GP ablation (n = 37), PVAI (n = 42), and extended PVAI (n = 41). The following parameters were studied: sinus rhythm restoration, vagal reactions, fluoroscopy time, procedure duration, lesion surface area. In 16 months after the procedure, echocardiography and Holter monitoring were performed.

Results

Significant differences were found in the amount of X-ray exposure, procedure duration, lesion surface area and vagal reactions. In all the cases, atrial mechanical function worsened after the procedure. However, there were no significant differences between the groups. Sixteen months after the procedure, sinus rhythm without antiarrhythmic therapy was maintained in 38% of patients in GP group, in 56% of patients in PVAI group and in 69% of patients in extended PVAI group.

Conclusions

In persistent AF, the extended PVAI is more effective than PVAI and GP ablation. After the PVAI or extended PVAI, abnormalities of the left atrial mechanical function occurred if the lesion area exceeded 25% of the total LA surface area.

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Imaging
Authors: Veronica Frank, Sonaz Shariati, Bettina Katalin Budai, Bence Fejér, Ambrus Tóth, Vince Orbán, Viktor Bérczi, and Pál Novák Kaposi

differentiating between mass forming pancreatitis and PDAC. In a multivariable logistic regression analysis, five radiomic parameters – surface area, percentile 40, inverse difference moment (IDM), long run emphasis (gray-level run-length matrix feature - GLRLM

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Imaging
Authors: Bettina Katalin Budai, Veronica Frank, Sonaz Shariati, Bence Fejér, Ambrus Tóth, Vince Orbán, Viktor Bérczi, and Pál Novák Kaposi

radiomics score model was compared with the clinical score and the combined score models. The combined score model included five radiomic features (surface-area-to-volume ratio, kurtosis, median, gray-level co-occurrence matrix contrast, and size zone

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Acta Microbiologica et Immunologica Hungarica
Authors: Lóránd Dénes, Zsuzsanna Pap, Annamária Szántó, István Gergely, and Tudor Sorin Pop

The vomeronasal organ (VNO) is the receptor structure of the vomeronasal system (VNS) in vertebrates. It is found bilaterally in the submucosa of the inferior part of the nasal septum. There are ongoing controversies regarding the functionality of this organ in humans. In this study we propose the immunohistochemical evaluation of changes in components of the human vomeronasal epithelium during foetal development. We used 45 foetuses of different age, which were included in three age groups. After VNO identification immunohistochemical reactions were performed using primary antibodies against the following: neuron specific enolase, calretinin, neurofilament, chromogranin, synaptophysin, cytokeratin 7, pan-cytokeratin and S100 protein. Digital slides were obtained and following colorimetric segmentation, surface area measurements were performed. The VNO was found in less than half of the studied specimens (42.2%). Neuron specific enolase and calretinin immunoexpression showed a decreasing trend with foetal age, while the other neural/neuroendocrine markers were negative in all specimens. Cytokeratin 7 expression increased with age, while Pan-Ctk had no significant variations. S100 protein immunoexpression also decreased around the VNO. The results of the present work uphold the theory of regression of the neuroepithelium that is present during initial stages of foetal development.

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Acta Microbiologica et Immunologica Hungarica
Authors: Ozgur Pilanci, Sevgi Ergin, Serhat Sirekbasan, Idris Ersin, Zafer Habip, Pelin Yuksel, Nuray Kuvat, Mustafa Aslan, Oyku Dinc, Suat Saribas, and Bekir Kocazeybek

Infection and septic complications in burn patients can be monitored by procalcitonin (PCT) and neopterin plasma values. The aim of the study was to investigate serum neopterin and PCT levels with WBC (white blood cell) and CRP (C-reactive protein) levels in patient group (PG) and healthy control group (HCG) and to investigate the relationship of these markers with burn wound infections (BWI). As the PG, 23 patients between 0–12 ages and up to 30% Total Body Surface Area (TBSA) burned and 15 HCG were included. PCT, neopterin, WBC, and CRP results on the first, the seventh, the fourteenth and the 21st day have been compared. During the follow-up period, 11 patients with BWI and 12 patients without BWI were classified as infected and non-infected patients, respectively. PCT and neopterin levels were detected higher in patients with BWI but no significant difference were present. Also, PCT and neopterin levels within the first 24 hours following the burn were detected higher in PG than HCG. CRP and WBC levels were detected high due to burn trauma. PCT and neopterin levels were increased in patients with BWI. PCT levels were increased during the pre-infectious period, while neopterin levels increased during the post-infectious period.

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Abstract

Objectives

Oral manifestations recorded for congenital heart disease (CHD) patients include teeth hypoplasia and high caries incidence. These observations suggested that the enamel and dentin of the teeth may be altered, increasing the risk for caries incidence. This study was designed to investigate the eff ect of CHD on the ultrastructure and composition of deciduous sound teeth.

Methods

Thirty sound exfoliated human deciduous incisor teeth were selected for this study. They were divided into three groups, Group I (control) from healthy children (n = 6), Group II from acyanotic CHD children (n = 12) and Group III from cyanotic CHD children (n = 12). Each tooth was longitudinally sectioned, providing enough specimens for ultrastructure and chemical analysis using ESEM/EDAX. The results of ESEM/EDAX and dentin image analysis were statistically analyzed using one-way ANOVA test followed by Tukey's test.

Results

Enamel of groups II and III showed increased dissolution and irregular orientation of enamel prisms. Orifices of dentinal tubules demonstrated widening and irregular outlines, also lateral branching increased markedly. Image analysis of dentin ESEM photomicrographs showed a highly significant increase in surface area of dentinal tubules. Decrease in calcium (Ca) and phosphorus (P) levels was statistically significant (P < 0.05).

Conclusions

CHDs affect the structure and chemical composition of deciduous teeth.

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Absztrakt:

Az etopozid egy topoizomeráz-II-gátló daganatellenes kemoterápiás szer, amelyet széles körben használnak hematológiai malignitások és szolid tumorok kezelésére. Terápiás indexe magas, használata számos rövid és hosszú távú mellékhatáshoz vezet, amelyek csökkentik a betegek gyógyulási esélyét. Dozírozása testfelület-alapú számítással történik, személyre szabott terápiás ajánlás jelenleg nincs. A gyógyszer biotranszformációjában és szállításában számos enzim és transzporter vesz részt; az etopozid farmakogenetikájáról is rendelkezünk ismeretekkel. Napjainkban előtérbe kerültek a farmakoepigenetikai kutatások is, ezért a szerzők betekintést kívánnak nyújtani az etopozid-útvonalat érintő epigenetikai változások kutatásába, kiemelve azokat a tanulmányokat, amelyek az enzimekre és a transzporterekre fókuszáltak. A jövőben az etopozid-útvonal epigenetikai változásai vélhetően fontos szerepet tölthetnek be a diagnosztikában, a prognosztikában és a személyre szabott terápiában. Orv Hetil. 2018; 159(32): 1295–1302.

Open access

Tapasztalataink a rekeszsérvek laparoszkópos sebészetével

Our experience with the laparoscopic surgery of hiatal hernias

Orvosi Hetilap
Authors: Máté Csucska, Mittal Sumeet K., Balázs Kovács, Tamás Kremzer, Lilla Ozorai, Zoltán Lóderer, and Árpád Juhász

–1962. 9 Granderath FA, Schweiger UM, Pointner R. Laparoscopic antireflux surgery: tailoring the hiatal closure to the size of hiatal surface area. Surg Endosc. 2007; 21: 542

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A tüdő immunfiziológiája – útjelzők a terra incognita felé

Immunophysiology of the lung – road signs to the terra incognita

Orvosi Hetilap
Author: Péter Balogh

Összefoglaló. A tüdő a benne lévő légutak és a légzőhám felületének kiterjedtsége, valamint a folyamatos napi gázcsere mennyisége miatt az emlősszervezetnek a környezeti antigének számára legnagyobb mértékben kitett közvetlen behatolási kapuja. A különböző antigénekkel szemben számos fizikai-mechanikai tisztulási folyamat, valamint helyi és szisztémás immunológiai védelmi mechanizmus együttesen biztosítja a légutak átjárhatóságát és a megfelelő gázcseréhez a légzőhám és a tüdő interstitialis összetevőinek szöveti integritását. A tüdő – veleszületett és adaptív immunológiai – védelmét ellátó molekuláris és sejtes résztvevőkre, ezáltal a légutak alapvető életfontosságú működésének biztosítására vonatkozó ismereteink az utóbbi időben számos új megfigyeléssel bővültek, melyek felvetik a tüdő immunológiai szerveződésének egyedi szerkezeti és funkcionális specializációját. A jelen összefoglaló célja ezeknek az új eredményeknek a bemutatása, ezen keresztül a tüdőben zajló sokrétű immunológiai folyamatok főbb jellemzőinek és a bennük részt vevő sejtes és molekuláris összetevőknek az áttekintése. Ezek részletesebb megismerése elősegítheti a légúti (köztük a SARS-CoV-2 általi) fertőzések után fellépő, helyi és szisztémás immunpatológiai események pontosabb megértését és a lehetséges terápiás eljárások kritikai értelmezését. Orv Hetil. 2021; 162(29): 1147–1155.

Summary. Due to the size of the surface area of airways and respiratory epithelium combined with the daily amount of continuous gas exchange, in mammalians the lung represents the most exposed organ serving as immediate entry port for airborne antigens. Together with several physicochemical clearance processes, both local and systemic immunological defense mechanisms ensure the passage of airways and the tissue integrity of respiratory epithelium and pulmonary interstitium necessary for the maintenance of gas exchange. Several recent observations concerning the molecular and cellular constituents of the pulmonary immunological defense have substantially broadened our knowledge of the maintenance of the vital functionality of airways, raising the unique specialization of the organization of pulmonary immune compartment. The purpose of the present review is to highlight the main findings on the complexity of pulmonary immunity, including the overview of the main characteristics of its cellular and molecular participants. Unrevealing these mechanisms may promote our understanding the local and systemic immunopathological processes occurring after airway infections (including SARS-CoV-2) and the critical assessment of potential therapeutic interventions. Orv Hetil. 2021; 162(29): 1147–1155.

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