Authors:Sweta Jha, Ashok Bhagwat, and Nancy Pandita
The γ-amino butyric acid (GABA) is the main inhibitory neurotransmitter system in the brain. Either imbalance in the extreme can result in several mental diseases like schizophrenia, cerebral stroke, temporal lobe epilepsy (TLE), Parkinson’s disease (PD), Huntington’s disease (HD), and anxiety disorders even death. Measurement of GABA in tissue will help to elucidate the metabolic role and diagnostic value. Various analytical techniques are employed to estimate GABA in biological samples but the experimental procedure and tedious techniques are required. The present study demonstrates a simple, feasible, and cost-effective high-performance thinlayer chromatography (HPTLC) method for estimation of GABA in mice brain tissue. The method was validated in terms of specificity, linearity, and detection limit. The precision was done for inter-day, intra-day, instrumental, and reproducibility. Accuracy was checked by recovery study. The results indicate that this method is fast, sensitive, and suitable for quantitative assessment.
Authors:V. Chaltikyan, A. Papoyan, H. Oshita, H. Shiotani, K. Ono, M. Ishikawa, and M. Ozawa
The cesium isotope 135Cs has an extremely long half-life (τ1/2 = 2.3 · 106 y) and its high water solubility leads to the anxiety of exudation to ground water during geological disposal. Such a LLFP
135Cs would be converted into 136Cs (Its half-life is 13.16 d and it becomes stable 136Ba) by neutron capture reaction. However intermingling 133Cs of which the natural abundance is 100% disturbs this nuclear converting reaction because 133Cs also absorbs neutrons and produces 135Cs again. For separating 135Cs from other cesium isotopes, laser-chemical isotope separation (LCIS) is believed to be suitable mainly due to the light
absorption and emission stability. Isotope separation of alkali metal 85Rb/87Rb was successfully achieved, showed 23.9 of head separation factor by LCIS. The measured isotope shift of Cs D2 line is within the reach of available semiconductor lasers having emission line width of less than 1 MHz, which shows that
the selective excitation of 135Cs may turn to be possible. It is known that cesium excited to the 62P3/2 state may forms cesium hydride while ground-state cesium does not. Therefore if the lifetime of 62P3/2 state is sufficiently longer than the inverse rate of the chemical reaction, 135Cs can be extracted as cesium hydride. Applicability of the Doppler-free two-photon absorption method for selective excitation
and further evaluation on Rydberg states and ionization should be investigated.
Technostress is a modern disease of adaptation caused by an inability to cope with the new computer technologies in a healthy manner. It manifests itself in two distinct but related ways: in the struggle to accept computer technology, and in the more specialized form of overidentification with computer technology. The primary symptom of those who are ambivalent, reluctant, or fearful of computers is anxiety. The primary symptom among those who have too fully identified with the computer technology is a loss of the capacity to feel and to relate to others. Signs of the technocentered state include a high degree of factual thinking, poor access to feelings, an insistence on efficiency and speed, a lack of empathy for others, and a low tolerance for the ambiquities of human behavior and communication. As its most serious, this form of technostress can cause aberrant and antisocial behavior and the inability to think intuitively and creatively. In some cases spouses report that their technostress partners began to view them as machines.
serotonin re-uptake inhibitor (SSRI). It is prescribed in many pathologies, such as generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder, and depression [ 2 – 4 ].
Paroxetine hydrochloride is a typical pseudo
Authors:Zdravka Zaharieva, Dimitar Tanev, and Dancho Danalev
prescription-only medicines can lead to a variety of health risks that present a serious risk, such as cardiovascular disease, liver disease, kidney failure, agitation, anxiety, confusion, depression, etc. For this reason, the World Health Organization (WHO
Authors:Chen Cheng, Nie Cun-Xi, Liang Jing, Wang Yong-Qiang, Liu Yan-Feng, Ge Wen-Xia, and Zhang Wen-Ju
undetectable since it was over covered by acetone signal peak. The method had been abandoned because of the anxiety about the proceeding loss of few remaining amount of gossypol during the process. The antioxidant NADPH-Na 4 [ 17 , 18 ] or glutathione
Authors:M. Nurul Islam, F. Downey, and C. K.-Y. Ng
Scutellaria L. is a diverse genus of the Lamiaceae (Labiatae) family of over 300 herbaceous plants commonly known as skullcaps. Various species of Scutellaria are used as ethnobotanical herbs for the treatment of ailments like cancer, jaundice, cirrhosis, anxiety, and nervous disorders. Scutellaria incana L., commonly known as the Hoary skullcap, is a traditional medicinal plant used by native Americans as a sedative for nervousness or anxiety. S. incana metabolites were identified by comparing their high-performance liquid chromatography (HPLC) retention times and mass spectra with those of the corresponding authentic standards. Where standards were unavailable, the structures were characterized on the basis of their tandem mass spectrometry (MS/MS) spectra following collision-induced dissociation (CID) and the accurate masses of the corresponding deprotonated molecules [M-H]− (mass accuracy ± 5 ppm). A total of 40 flavonoids, including two phenolic glycosides, were identified from leaves, stems, and roots of S. incana. Differences in the flavonoid composition between leaves, stems, and roots in S. incana were observed although the flavonoid profile of S. incana is consistent with other Scutellaria species. Further work should focus on assessing the potential of S. incana as a source of these bioactive metabolites.
Authors:Gulab Khan Rohela, Prasad Bylla, Sreenu Pendli, Rajender Korra, Rajender Gandu, and Christopher Reuben
major alkaloid with more pharmaceutical applications is reserpine, which is used mostly for the treatment of hypertension [ 15 ], treatment of insomnia, cardiovascular diseases, anxiety and other mental disorders [ 16 ].
An alkaloid known as
Authors:Jiaxing Fan, Yiyang Liu, Shenmin Su, Yiqing Cao, and Yunqiu Yu
[ 25, 26 ]. Psoriasis patients, in addition to suffering from diseases, often also bear a great psychological burden and are prone to anxiety, inferiority, self-injury, and even depression, which affects quality of their life seriously [ 27 ]. The