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Authors: A. Molnár, P. Sarlós, G. Fáncsi, J. Rátky, Sz. Nagy and A. Kovács

Semen of an infertile Dutch White (Saanenthal) goat buck was examined. Light and electron microscopic examinations showed aberrations of the sperm tails resembling the so-called Dag or Dag-like defects described in several cattle breeds. Ejaculated semen showed that virtually all of the cells had strongly coiled or broken tails, or fractured midpieces. Ultrastructural investigations by transmission electron microscopy (TEM) showed uneven distribution of the mitochondria in the midpiece. Coiled tails were encapsulated by a common membrane, and dislocated axial fibres and different membranous structures were also present. The ultrastructural characteristics of the defective sperm tails, the missing parts of the axial fibre bundle and the misalignment of the mitochondria indicate that this first case reported in goat is similar to the Dag-like defect in cattle.

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The addition of synthetic eugenol and benzyl acetate to the known floral chemical and moth attractant phenylacetaldehyde synergized attraction of the silver Y moth Autographa gamma, an important noctuid pest. Traps baited with the ternary blend caught 2 to 6 times more A. gamma moths than traps baited with phenylac-etaldehyde alone. Both female and male moths were attracted, supposedly in the natural sex ratio of the local population. More A. gamma were caught when the blend was formulated in dispenser types with higher release rates. Traps baited with the ternary lure in polyethylene bag dispensers caught 20% to 34% as many moths as were caught in traps baited with synthetic sex pheromone, suggesting that this improved bisexual lure could be efficient enough to yield a new tool for detection and monitoring of female and male A. gamma, for more reliable plant protection decisions.

The same ternary lure also improved trap catches of moths over phenylacetaldehyde alone for the plusiinae pests MacDunnoughia confusa (in Europe) and Autographa californica (in North America) and for the Noctuinae cutworm Xestia c-nigrum (in North America).

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Glycine is a mandatory positive allosteric modulator of N-methyl-D-aspartate (NMDA)-type ionotropic glutamate receptors in the central nervous system. Elevation of glycine concentrations by inhibition of its reuptake in the vicinity of NMDA receptors may positively influence receptor functions as glycine B binding site on NR1 receptor subunit is not saturated in physiological conditions. Synaptic and extrasynaptic concentrations of glycine are regulated by its type-1 glycine transporter, which is primarily expressed in astroglial and glutamatergic cell membranes. Alteration of synaptic glycine levels may have importance in the treatment of various forms of endogenous psychosis characterized by hypofunctional NMDA receptors. Several lines of evidence indicate that impaired NMDA receptor-mediated glutamatergic neurotransmission is involved in development of the negative (and partly the positive) symptoms and the cognitive deficit in schizophrenia. Inhibitors of glycine transporter type-1 may represent a newly developed therapeutic intervention in treatment of this mental illness. We have synthesized a novel series of N-substituted sarcosines, analogues of the glycine transporter-1 inhibitor NFPS (N-[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)-propyl]sarcosine). Of the pyridazinone-containing compounds, SzV-1997 was found to be a potent glycine transporter-1 inhibitor in rat brain synaptosomes and it markedly increased extracellular glycine concentrations in conscious rat striatum. SzV-1997 did not exhibit toxic symptoms such as hyperlocomotion, restless movements, respiratory depression, and lethality, characteristic for NFPS. Besides pyridazinone-based, sarcosine-containing glycine transporter-1 inhibitors, a series of substrate-type amino acid inhibitors was investigated in order to obtain better insight into the ligand-binding characteristics of the substrate binding cavity of the transporter.

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Authors: I. Gresits, S. Tölgyesi, J. Solymosi, R. Chobola, L. Nagy, T. Past, L. Szabó and P. Ormai
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Authors: D. Vuono, C. C. Pavel, P. De Luca, J. B. Nagy and A. Nastro

Summary The ETS-10 is a newly formed titano-silicate the structure of which was resolved thanks to the XRD, EDS, HREM and mass NMR. The ETS-10 is a potentially good catalyst. The aim of this research is to study the physicochemical properties of ET(Zr)S-10 obtained from a gel containing different amounts of Zr. The analyses used are XRD, thermal analysis (TG-DSC), SEM, and 29Si NMR.

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Abstract

Hepatitis C (HCV) is one of the main causes of liver transplantation (OLT). Previously we have reported that high serum C RNA level correlates with the severity of histopathological signs and poor clinical outcome. The core antigen of virus C is known to interfere with chaperones in the hepatocytes, results in an endoplasmic reticulum (ER) stress. In this study HCV positive liver transplanted patients were evaluated, whether there are correlations among chaperone expression, recurrence and viral titer. Patients were enrolled after surviving the first month following OLT. Sera were collected regularly, and biopsies were taken on demand following OLT. The diagnosis of recurrent HCV was proven by Knodell-Ishak scoring. In this case ribavirin+interferon were initiated, and maintained for one year. All chaperones were upregulated in the transplanted liver graft showing recurrent hepatitis C disease. ATF6, GP96, GRP78, CNX and CLR chaperones were upregulated significantly compared to their levels in normal livers. Except for one chaperone, the level of upregulation did not correlate with the serum's HCV-RNA titre: the only difference between Group1 and 2 (RNA titre above and below 8.78 106 respectively) was that the level of ATF6 was 1.6 times higher in Group1 compared to Group2. The expression of all chaperones was reduced, and some even became downregulated after the interferon treatment. In accordance with the literature our results suggest that hepatitis C might induce apoptosis through ER-stress. Those cells exposed to a high C viral load, had a lower chance to be eliminated.

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Authors: Z. Kemencei, R. Farkas, B. Páll-Gergely, F. Vilisics, A. Nagy, E. Hornung and P. Sólymos

We determined microhabitat associations for 39 land snail species based on multimodel inference and generalized linear mixed models using a comprehensive and micro-scale data set from the Aggtelek Karst Area, Hungary. Patterns of microhabitat associations were highly nested among microhabitat types (litter, live trees, dead wood, rock) with high number of specialist species in dead wood and in rock microhabitats. Species composition was highly predictable in these microhabitats as opposed to live tree and litter faunas. Species richness was affected by microhabitat, topographic factors and local moisture conditions. Species richness in dead wood and rock microhabitats remained high irrespective of the topographic effects as opposed to litter and live tree microhabitats, where richness decreased with drier microhabitat conditions due to topography. Our results imply that consideration of topographic factors and microhabitat quality as part of coarse filter conservation measures could be beneficial to local land snail populations in the face of changing climate and disturbance regimes.

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Authors: Balázs Nemes, Réka P. Szabó, László Bidiga, Károly Kalmár Nagy, Lóránt Illésy and Anikó Szilvási

Absztrakt:

A veseátültetés utáni hosszú távú túlélést befolyásoló tényezők egyike az antitestmediált rejekció (ABMR). A szerzők áttekintést nyújtanak az ABMR jelenleg ismert diagnosztikai és kezelési hátteréről. A Debreceni és a Pécsi Egyetem transzplantációs központjainak együttműködése alapján áttekintik a 2013 és 2017 közötti időszakban végzett veseátültetések után kialakult korai ABMR-eseteket és a releváns közleményeket. A két központban összesen 454 veseátültetés történt. ABMR-diagnózist összesen 18 esetben állítottunk fel (4%). Minden esetben perkután biopszia történt. A betegek közül 22% volt primer, 78% retranszplantált eset. Az átlagéletkor 51,2 ± 6 év volt. A veseátültetés után az ABMR diagnózisáig eltelt idő 15,4 ± 22,1 hónap volt. A C4d-pozitivitást 7 esetben sikerült igazolni, ami az összes ABMR-eset 39%-a. Összesen 16 betegnél történt szteroidbolus + intravénás immunglobulin (IVIG) + plazmaferézis (PF) kezelés, a 6 debreceni beteg közül 5 kapott ezenfelül rituximabot és 1 alemtuzumabot. 9 (47,4%) beteg él működő beültetett vesével, 4 beteg meghalt (21%), és 5 került vissza művesekezelésre graftvesztés miatt (31%). Az ABMR veszélyes szövődmény a veseátültetés után. A diagnosztikus kritériumok sokáig változtak. A gold standard a szövettan. A C4d-esetekben is lehet akcelerált ABMR. A retranszplantáción átesett fiatalabb, preformált donorspecifikus antitesttel (DSA) jelentkező betegek és azok, akik EC-donorból kapnak vesét, kockázati csoportot jelentenek. A de novo DSA megjelenése, az átlagos fluoreszcenciaintenzitás (MFI) kinetikája lehet az a pont, amely felhívja a figyelmet az akut ABMR veszélyére. A rituximab hatékonyságát megkérdőjelezik, az új gyógyszerekkel (belatacept, bortezomib vagy ekulizumab) még nincs elég tapasztalat, vagy rendkívül drágák. Saját anyagunkban a 40% feletti gyógyulási arány kiemelkedően jó eredmény. Orv Hetil. 2018; 159(46): 1913–1929.

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Abstract  

The aim of this work is the synthesis and the characterization of a microporous material obtained from gels with titanium and silicon: NTS (titanosilicate). The structure of NTS zeotype is similar to that of AM-1 and JDF-L1 (titanosilicates). The synthesis were carried out with gels of composition: 3.5Na2O–yTiO2–4.48HCl–xSiO2–110H2O with 1.0≤x≤12.0 and 0.2≤y≤0.7. The temperature of reaction was 1902C. In most of the cases NTS was prepared in a pelletted form. NTS pellets are produced at TiO2 content higher than 0.3 moles and SiO2 comprised between 3 and 7. NTS in a powder form is produced for TiO2<0.3 and SiO2 between 3 and 5 moles. It describes crystallization field and the kinetic curves of the titanosilicate. The samples are characterized by X-ray diffraction (XRD), thermogravimetry (TG), derivative thermogravimetry (DTG), differential scanning calorimetry (DSC), nuclear magnetic resonance spectroscopy-high resolution solid state MAS 29Si-NMR, scanning electron microscope (SEM), energy dispersive spectroscopy (EDS) X-ray microanalysis.

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Abstract  

The radiation dose of workers and patients resulting from inhaling radon and through the consumption of spring waters was examined in the hospital near the Héviz lake in Hungary. The radiation dose originating from radon was 2.15–3.95 mSv·y−1 concerning workers at the spa. The radiation dose originating from radon in the case of those regularly taking a bath was an average of 0.75 mSv·y−1. Due to the limited duration of treatments a bound effective dose of maximum 100 µSv·y−1 may originate from radon and inhaling radon, while a maximum of 1.4 µSv·y−1 may originate from ingestion of 222Rn, 226Ra, 234U and 238U radionuclides.

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