Authors:Guo Jin-xin, Sun Si-xiu, Zhu Rong-xiu, Yin Zhi-lei, Yu Hai-yun, Li Da-zhi, Zhang Wei-min, Xu Xian-gang, Sun Xuan and Shao Hua
The mechanism of solvent extraction of uranium(VI) from highly concentrated chloride solution with a quaternary ammonium salt,
benzyloctadecyldimethylammonium chloride (BODMAC, R4NCl), dissolved in chloroform was studied. The compositions of the extracted species were R4N.UO2Cl3 and (R4N)2.UO2Cl4. The extraction process is exothermic (ΔH° = -8.42±0.54 KJ/mol). Kex1 and Kex2 are calculated to be (3.62±0.55).10-2 and (1.06±0.17).103, respectively. In the extraction process, a W/O uranium(VI) rich emulsion solution has been formed between the organic and
aqueous phases, its volume increased with the increase of BODMAC in the system. The influences of temperature, NaCl, MgCl2 and MgSO4 concentrations on the extraction equilibrium were also studied.
Authors:Li-Fang Song, Chun-Hong Jiang, Jian Zhang, Li-Xian Sun, Fen Xu, Wan-Sheng You, Yi Zhao, Zhi-Heng Zhang, Mei-Han Wang, Yutake Sawada, Zhong Cao and Ju-Lan Zeng
A novel metal-organic frameworks [Cu2(OH)(2,2′-bpy)2(BTC) · 2H2O]n (CuMOF, BTC = benzene-1,3,5-tricarboxylic acid, 2,2′-bpy = 2,2′-bipyridine) has been synthesized hydrothermally and characterized
by single crystal XRD, FT-IR spectra. The low-temperature molar heat capacities were measured by temperature modulated differential
scanning calorimetry (TMDSC) for the first time. The thermodynamic parameters such as entropy and enthalpy relative to reference
temperature 298.15 K were derived based on the above molar heat capacity data. Moreover, the thermal stability and the decomposition
mechanism of CuMOF were investigated by TG-MS (thermogravimetry-mass spectrometer). A four-stage mass loss was observed in
the TG curve. MS curve indicated that the gas products for oxidative degradation of CuMOF were H2O, CO2, NO and NO2.
Authors:Chuan-Min Qi, Yong He, Xiao Wang, Man Feng, Jing-Li Xu, Rui Ding, Hang Liu, Yu-Rong Chen, Fang Li, Zhao-Hui Zhu, Yong-Hong Dang, Shu-Ting Zhang and Ying Xie
d-glucosamine at concentration of certain range could kill tumor cells without influencing normal cells. There are also some
reports on the antitumor activity of d-glucosamine and its derivatives in murine models. It was therefore postulated that d-glucosamine might have the potential to invade tumor cells. We designed and radiosynthesized a glucosamine derivative, N-(2-[18F]fluoro-4-nitrobenzoyl)glucosamine ([18F]FNBG([18F]7)). Evaluations in vitro and in vivo were performed on tumor bearing mice. Excitingly, the radiochemical purity of [18F]FNBG([18F]7) was 99%, and besides the best radiochemical yield was up to 35%. The best T/Bl (Tumor/Blood) and T/M (Tumor/Muscle) ratios
of [18F]FNBG([18F]7) were 4.40 and 4.84. Although [18F]FNBG([18F]7) deserved further studies, the results revealed it might become a potential PET imaging agent for detecting tumors.
Authors:Yong He, Rui Ding, Hang Liu, Xiao Wang, Jing-Li Xu, Man Feng, Yu-Rong Chen, Chuan-Min Qi, Cheng Peng, Zhao-Hui Zhu, Yong-Hong Dang, Ming Wang and Yun-Chuan Ma
As degradation product of Antineoplaston A10 in vivo, phenylacetyl glutamine showed antitumor activities. According to literatures,
we designed and radiosynthesized a phenylacetyl glutamine derivative, which was achieved under a mild reaction condition.
Evaluations in vitro and in vivo were performed on tumor bearing mice. Excitingly, the radiochemical purity of (S)-2-((S)-2-(4-(3-fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic
acid ([18F]FBPPA) was 98%, and besides the best radiochemical yield was up to 46%. T/Bl (Tumor/Blood) and T/M (Tumor/Muscle) ratios
of [18F]FBPPA at 60 min post injection were 2.33 and 3.51. Meanwhile, it showed satisfied stability in vitro and in vivo, compared
with 2-[18F]fluorodeoxyglucose ([18F]FDG). Although [18F]FBPPA deserved further studies to make optimizations on its structure, the results revealed it might become a potential
PET imaging agent for detecting tumors.
3-(4-[18F]fluorobenzyl)-8-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one ([18F]FHTP) was in vitro and in vivo evaluated as a putative dopamine D4 receptor radioligand. Its inhibition constant (Ki) for cloned human dopamine D4.2 receptor was determined to be 2.9 nM and it displayed a 2000-fold D4-selectivity over the D2long subtype. Its partition coefficient (logP) was measured to be 1.11. Biodistribution, blocking distribution and metabolism studies in rats demonstrated that the specific
distribution of [18F]FHTP in brain regions, suggesting that [18F]FHTP may be a suitable PET imaging agent for in vivo studies of the dopamine D4 receptor.