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Authors: Yishan Wu, Yuntao Pan, Yuhua Zhang, Zheng Ma, Jingan Pang, Hong Guo, Bo Xu, and Zhiqing Yang


This paper traces the history of China Scientific and Technical Papers and Citations database (CSTPC) since its founding in 1988. The fact that most Chinese scientists publish their research results in Chinese journals requires that China establish SCI counterparts dedicated to domestic S & T journals. The article describes the selection criteria for source journals, the approach used to adjust the structure of source journals, the criteria for selecting items to be included in the database, and the indexing method. Then it discusses the impact upon government R & D administration agencies and the science community in general by both CSTPC team and CSTPC database. Finally, the article analyzes the main factors that lead to the primary success of CSTPD. The authors encourages information workers in other non-English developing countries to build up similar databases.

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Bicalutamide (BCL) has been approved for treatment of advanced prostate cancer (Pca), and vitamin D is inevitably used in combination with BCL in Pca patients for skeletal or anti-tumor strategies. Therefore, it is necessary to study the effect of vitamin D application on the pharmacokinetics of BCL.

We developed and validated a specific, sensitive and rapid UHPLC–MS/MS method to investigate the pharmacokinetic behaviours of BCL in rat plasma with and without the combined use of vitamin D. Plasma samples were extracted by protein precipitation with ether/dichloromethane (2:1 v/v), and the analytes were separated by a Kinetex Biphenyl 100A column (2.1 × 100 mm, 2.6 μm) with a mobile phase composed of 0.5 mM ammonium acetate (PH 6.5) in water (A) and acetonitrile (B) in a ratio of A:B = 35:65 (v/v). Analysis of the ions was run in the multiple reactions monitoring (MRM) mode. The linear range of BCL was 5–2000 ng mL−1. The intra- and inter-day precision were less than 14%, and the accuracy was in the range of 94.4–107.1%. The mean extraction recoveries, matrix effects and stabilities were acceptable for this method. The validated method was successfully applied to evaluate the pharmacokinetic behaviours of BCL in rat plasma. The results demonstrated that the pharmacokinetic property of BCL is significantly affected by combined use of vitamin D, which might help provide useful evidence for the clinical therapy and further pharmacokinetic study.

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