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  • Author or Editor: M. F. Hassan x
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Thermal analysis of pharmaceutical compounds

III. Characterization of sulphonamides by thermal analysis

Authors: F. I. Khattab, N. Y. M. Hassan and M. M. Amer

Fourteen sulphonamides have been thermally analyzed using thermogravimetry (TG), derivative thermogravimetry (DTG) and differential thermal analysis (DTA). Their thermal reactions and stabilities have been thoroughly studied. It was found that the sulphonamides are first transformed into sulphanilamide. The melting points of these sulphonamides have been determined through their DTA curves and by the Kofler microscope, the results agreeing with those reported in the literature. The amount of water of crystallization has been calculated from the TG and DTG curves. Analysis of mixtures of some sulphonamides has been achieved by thermal analysis and by thin-layer chromatography using different solvent systems.

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Authors: Omar M. Khalaf, Mosad A. Ghareeb, Amal M. Saad, Hassan M. F. Madkour, Ahmed K. El-Ziaty and Mohamed S. Abdel-Aziz

Different solvent extracts of the aerial parts of Senna italica (Mill.) were investigated for their chemical constituents and biological activities. Moreover, bio-guided fractionation led to isolation and identification of six compounds, namely: physcion (1), emodin (2), 2-methoxy-emodin-6-O-β-d-glucopyranoside (3), 1-hydroxy-2-acetyl-3-methyl-6-hydroxy-8-methoxynaphthalene (tinnevellin) (4), quercetin 3-O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (rutin) (5), and 1,6,8-trihydroxy-3-methoxy-9,10-dioxo-9,10-dihydroanthracene (6). The chemical structures of these compounds were established via 1D and 2D 1H- and 13C-NMR spectroscopy. Ethyl acetate and n-butanol extracts as well as compound 3 were evaluated for their anticancer activity against tumor cell lines. The tested extracts showed a moderate to weak activity, while compound 3 showed a moderate activity against human liver cancer (Hep G2) and breast cancer (MCF-7) cell lines with IC50 values of 57.5 and 42.3 μg/mL, respectively. Both ethyl acetate and n-butanol extracts exhibited antimicrobial activities with different strengths, i.e., ethyl acetate exhibited antimicrobial activity against seven test microbes while n-butanol extract showed antimicrobial activity against all tested microbes. This is the first report for the isolation of compound 3 as a new compound from S. italica growing in Egypt.

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