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Using a simple flow reactor, the safe use of nitromethane at elevated reaction temperatures was demonstrated in a nitroaldol reaction of different aldehydes. The reaction products were isolated in good yields after a short reaction time.

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Different electrochemical microreactors for continuous flow synthesis are described in this review. Advantages of flow over batch type chemistry are highlighted as well as novel developments in construction of such devices.

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Electrosynthesis is an old method currently moving again in the focus of organic synthesis. Some limitations of conventional electrosynthesis can be overcome by the use of electrochemical flow devices. This perspective indicates where the pitfalls, where the advantages and where the challenges are in implementing flow electrosynthesis as an alternative tool for the synthetic chemist.

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Journal of Flow Chemistry
Authors: Alastair Baker, Michael Graz, Robert Saunders, Gareth J. S. Evans, Ilaria Pitotti and Thomas Wirth

Rapid alkylations of thiols are performed in a packed-bed flow reactor where potassium carbonate acts as a heterogeneous base in anhydrous solvents at ambient temperature. The reaction also has a high efficiency as the removal of the solvent is the only work up required to isolate the product. The products can be used in a subsequent oxidation which was performed sequentially in semibatch mode. The alkylations of phenol and benzyl amine have been demonstrated on an array of bases, but higher temperatures and longer reaction times are required than with thiols.

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Journal of Flow Chemistry
Authors: Alastair Baker, Michael Graz, Robert Saunders, Gareth J. S. Evans, Sandra Kaul and Thomas Wirth


Using mild conditions and short reaction times, symmetrical disulfides have been synthesized in flow chemistry using phase transfer catalysts to facilitate the substitution of organohalides with disodium disulfide. Also, the synthesis of symmetrical trisulfides was possible using this procedure with an additional equivalent of sulfur.

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