The direct production of anhydrous13F ion has been achieved through the incorporation of a new approach to hot atom reactions for reactor generated radiopharmaceuticals. Capitalizing on the traditional Li2CO3 method for hydrated18F production, a unique target design and geometry utilizing neutron generated energetic tritions emerging from the surface of a thin LiF embedded stainless steel matrix react with gaseous O2 to produce18F as a free recoiling anhydrous species. Approximately 10–15 MBq of reactive anhydrous18F ion absorbed onto a metallic foil has been produced by this method. Verification of the production of18F was substantiated through decay measurements using Ge(Li) spectroscopic analysis, and by the synthesis of18F-fluoromethane gas. Cyclotron gas target chemistry which has been instrumental in the preparation of18F-2FDG and other metabolic tracers may be reproduced using this technique by the addition of 1% F2 scavenger gas to a recirculating reactor gas handling system.