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  • Author or Editor: Ágnes Szabó x
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Chlamydophila pneumoniae is an obligate intracellular human pathogen, which causes acute respiratory tract infections and can also cause chronic infections.C. pneumoniae possess type III secretion system (TTSS), which allows them to secrete effector molecules into the inclusion membrane and the host cell cytosol. Low calcium response protein E (LcrE) is a part of TTSS. The gene of LcrE in a 6His-tagged form was cloned from C. pneumoniae CWL029, expressed and purified from Escherichia coli using the HIS-select TALON CellThru Resin, this gene was also cloned into a eukaryotic expression vector (pΔRC). One group of BALB/c mice received an intramuscular pΔRC inoculation then the mice were immunized with purified LcrE protein; the second group of mice was immunized two times with the recombinant plasmid (pΔRCLcrE), and the third group was primed with pΔRCLcrE inoculation then boosted with LcrE protein. LcrE-specific antibody response was induced by DNA immunization with a shift towards Th1 isotype pattern compared to protein-immunization, this shifting pattern was observed in plasmid primed then protein-boosted animals. DNA immunization given as a priming and followed by a protein booster significantly reduced the number of viable bacteria in the lungs after challenge with C. pneumoniae. These results confirm that immunization with pΔRCLcrE can be an effective part of a vaccination schedule against C. pneumoniae.

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Bakócz Tamás címerével ellátott tárgyak egykor az esztergomi főszékesegyházban •

Tárgyegyüttes-rekonstrukció a kincstár leltárai alapján

Objects carrying the coat of arms of tamás bakócz once in the cathedral of esztergom •

Reconstruction of an assortment of objects on the basis of treasury inventories
Művészettörténeti Értesítő
Author:
Ágnes Szabó

The study collects the liturgical textiles with connection to the person of Cardinal Tamás Bakócz (1497–1521), archbishop of Esztergom, which used to be in the cathedral sometime in the past. The method adopted is looking diachronically through the basilica treasury’s inventories and other, 16–18th century written sources (high priests’ testaments). The main aim of the research is to explore the history of the survival of the chasuble adorned with the cardinal-archbishop’s coat of arms and preserved in the treasury of Esztergom cathedral. Apart from collecting the paraments, the study also gives a glimpse of the maintenance of paraphernalia in the treasury of the Esztergom basilica and its history after the lost battle at Mohács in 1526.

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Abstract

Before the Coronavirus pandemic, the fitness industry was a growing sector globally, both in terms of the number of members and clubs; even prior to the global pandemic there were online workouts and technological innovations. With COVID-19, revenues plummeted, and many gyms went out of business. Consumers bought equipment for home use and switched to different types of online or outdoor workouts. This paper aims to investigate how the pandemic affected the fitness sector, and the consumer behavior of former gym members. Our assumption was that the preferences of gym-members had changed, and gyms would have prospered if they had changed their business models and moved to a hybrid model. We conducted in depth-interviews with Hungarian club owners and used an online questionnaire survey to collect data from members of gyms in Hungary. We asked them about exercise habits, home exercise methods, planned future exercise locations, the expectations of customers, safety measures, and service quality. Our assumptions were confirmed. The results may represent useful input for Hungarian fitness centers.

Open access

Abstract

The esport industry is emerging and constantly changing. The pandemic has had a significant impact on esport and its markets and has affected the whole ecosystem. The focus of this paper, besides esport, is simracing: due to the limitations on physical events, motorsports have had to convert their races to the digital world. The aims of the article are: (1) to identify the changes in the esport and simracing world and markets caused by the pandemic, (2) to examine the difficulties and challenges that the industry is facing, and (3) to explore the opportunities for the further development of the business. Our research methodology involved in-depth interviews with industry professionals from different backgrounds. The results show that esport and simracing need to become more economically sustainable, and changes are required in all related markets. This article identifies such opportunities. Despite the difficulties, esport will continue to be a major player in the digital world and in the world of sports.

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Kutatásunk célja a halálról alkotott elképzelések generációs értékítélet-különbségeinek összehasonlító vizsgálata a magyar társadalomban. A halállal kapcsolatos, leginkább félelmet keltő dimenziók mérésére kérdőíves vizsgálatot végeztünk, 178 fős célpopuláción. A felméréshez a Nei­meyer és Moore-féle Multidimenzionális Halálfélelem Skálát (MFODS, 42 tétel, 8 faktorba rendezve) használtuk. A skálát Lester Halál Iránti Attitűd Skálájával, a Rövidített Beck Depresszió Kérdőívvel és a STAI-T skálával validáltuk és bemértük. A statisztikai elemzés alapján a skála valid, jól mér a magyar populáción, a skálák egymással jól korrelálnak. Az MFODS eredeti faktorstruktúrája kirajzolódott a magyar mintán, az 5. faktor kivételével. A kapott eredmények - mint a fiatalok és a nők magasabb halálfélelme és szorongása - alátámasztják a szakirodalomban korábban közölt kutatási eredményeket.

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Abstract

Background

The aim of this study was to investigate the relationship between the attitudes displayed towards death by the youth and their mental health in the Hungarian population and to compare the results to data published in the literature. Our goal was to examine changes in the way youth conceived death, furthermore to examine the way youth perceived their own death within a small generational comparison study.

Methods

In order to measure the degree and possible dimensions of the fear of death in Hungarian young the Multidimensional Fear of Death Scale (MFODS) was used. The samples came from different socio-economic groups in Budapest, the capital of Hungary.

Results

The two highest anxiety factors were Fear for Significant Others and Fear of the Dying Process in all the examined groups. A significant difference in the overall fear of death was detected between the young and middle aged groups (p = 0.000) but the most characteristic difference was found between the young and older age groups.

Conclusions

This study confirmed previous observations in Western type societies being the first in Hungary to use the validated MFODS method. Improvement of communication within families, opening up channels of communication about death and dying together with the use and distribution of educational materials in schools may reduce fear of death and anxiety among young people.

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Better vaccines and new therapeutic drugs could be a successful breakthrough against intracellular bacteria. M. tuberculosis ABC transporter ATPase (Rv0986) plays a role in mycobacterial virulence by inhibiting phagosome-lysosome fusion. Thus, it could be a potential vaccine candidate. C. pneumoniae another important intracellular bacterium possesses a protein named CpB0255, which is homologous with the mycobacterial Rv0986. The aim of this study was the cloning, over-expression and purification of CpB0255 ABC transporter ATPase protein to study its biological properties. The immunogenicity and protective effect of recombinant chlamydial ATPase protein combined with Alum adjuvant were investigated in mice. The immunization resulted in the reduction of the number of viable C. pneumoniae in the lungs after challenge. Our results confirm that chlamydial ATPase induces protective immunity in mice.

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Papaver somniferum produces secondary metabolites which have important roles in self-defense processes, in plant biochemistry, and in allelochemistry. By performing experiments to determine how irregular stress effects changed the alkaloid content of poppies we have shown that different types of stress affect the quantities of alkaloids. Papaver somniferum (cv. ‘Kék Duna’, Budakalász, Hungary) plants were grown for 2 months, from seeds, in quartz-sand (natural light, temperature 24–28°C, in Knopf ’s nutritive solution). In this work we studied alkaloids in poppies subjected to two kinds of stress — mycotoxin and drought. Amounts of alkaloids were measured by different separation and detection procedures — thin-layer chromatography (TLC and HPTLC) with fluorescence detection, and high-performance liquid chromatography (HPLC). HPLC proved superior for identification and approximate estimation of the morphine alkaloids, but the effects of stress on poppy plants can be detected by use of either method. Drought stress resulted in higher levels of the alkaloids whereas mycotoxin stress did not result in significant differences.

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A várható élettartam hosszabbodásával egyre gyakoribbak a különféle reumatológiai és onkológiai megbetegedések, amelyek csontszövődményeinek csökkentésére széles körben alkalmaznak különböző per os és intravénás antireszorptív hatású készítményeket (például biszfoszfonátok). Ezek a szerek jótékony hatásuk mellett súlyos szövődményeket is okozhatnak, ilyen például a ma még nem teljesen tisztázott patomechanizmusú állcsontnecrosis. A szerzők célja egy átfogó szakmai tájékoztatás nyújtása a gyógyszer indukálta állcsontnecrosis lehetséges megelőzéséről és terápiájáról. A szakirodalmi áttekintés alapján készült dolgozat azokat a szűrőmódszereket ismerteti (előnyeikkel és limitációikkal együtt), amelyek segítségünkre lehetnek a gyógyszer indukálta állcsontnecrosis korai detektálásában. A szerzők a legújabb sebészi és adjuváns terápiás irányvonalakat is ismertetik. Megállapítják, hogy a patomechanizmus ismeretének hiányában jelenleg még hatékony terápiás modalitás nem áll rendelkezésre, és hangsúlyozzák mind a prevenció, mind a terápia során az interdiszciplináris együttműködés szükségességét és annak fontosságát. Jelenleg ez tűnik a gyógyszer indukálta állcsontnecrosis elleni leghatékonyabb eszköznek. Or. Hetil., 2014, 155(49), 1960–1966.

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