Authors:A. Blotcky, F. Hamel, A. Stranik, A. Ebrahim, R. Sharma, E. Rack, and S. Solomon
A method is described for determination of vanadium in biological tissues. This method consists of a wet digestion of the tissue with nitric acid followed by anion exchange chromatography, neutron irradiation, and radioassay. The chromatographic separation will allow the decontamination of vanadium from radioactivatable sodium and chlorine which are present in large quantities in biological tissues. The validity of the method is evaluated by employing NBS-SRM 157 and 157a Bovine Liver employing the method of standard additions. The method is successfully applied to human, cow and rat liver specimens. The detection limit of the method is one ppb.
Authors:A. Blotcky, W. Duckworth, A. Ebrahim, F. Hamel, E. Rack, and R. Sharma
Vanadium in serum was investigated by pre-irradiation chemistry neutron activation analysis employing anion exchange chromatography and post-irradiation neutron activation employing solvent extraction techniques. From a comparison of these techniques it is concluded that vanadium is present in human serum in the sub-ppb range.
Authors:L. Yahaghi, Parichehreh Yaghmaei, N. Hayati-Roodbari, S. Irani, and A. Ebrahim-Habibi
Betanin is a betacyanin with antioxidant and anti-inflammatory activities whose effects were investigated in a nonalcoholic steatohepatitis (NASH) model.
Ninety-six male naval medical research institute (NMRI) mice were divided into eight groups (n = 12) including normal control, high fat diet (HFD), Sham, and positive control treated with trans-chalcone. Three experimental groups were treated with 5 mg/kg, 10 mg/kg or 20 mg/kg betanin, and a betanin protective group was also defined.
Four weeks of HFD treatment resulted in steatohepatitis with associated fibrosis. Significant increase was observed in serum levels of triglycerides (TG), total cholesterol (TC), glucose, insulin, leptin, liver enzymes, malondialdehyde (MDA), furthermore insulin resistance and (sterol regulatory element-binding protein-1c) SREBP-1c were detected. Levels of high-density lipoprotein cholesterol (HDL-C), adiponectin, superoxide dismutase (SOD), catalase (CAT), and PPAR-α (peroxisome proliferator-activated receptor-α) considerably decreased. Treatment by betanin, particularly the 20 mg/kg dosage, attenuated these changes.
Betanin is a potential treating agent of steatohepatitis and works through up-regulation of PPAR-α, down-regulation of SREBP-1c, modification of adipokine levels and modulation of lipid profile.
Authors:Ebrahim Hashemi, Fatemeh Shokuhifar, and Abdollah Alhevaz
The intersection of all maximal right ideals of a near-ring N is called the quasi-radical of N. In this paper, first we show that the quasi-radical of the zero-symmetric near-ring of polynomials R0[x] equals to the set of all nilpotent elements of R0[x], when R is a commutative ring with Nil (R)2 = 0. Then we show that the quasi-radical of R0[x] is a subset of the intersection of all maximal left ideals of R0[x]. Also, we give an example to show that for some commutative ring R the quasi-radical of R0[x] coincides with the intersection of all maximal left ideals of R0[x]. Moreover, we prove that the quasi-radical of R0[x] is the greatest quasi-regular (right) ideal of it.