Authors:Z. Jancsó, H. Márton, A. Simay, I. Újhelyi, and I. Ilyés
Study was aimed to assess the effect of eating habits on cardiovascular risk factors and the assumed cardiovascular risk among 18–60 years old individuals in Hungary. The 1320 patients were recruited who had not been treated previously because of known cardiovascular risk factors or diseases. Taking questionnaire on eating habits, physical examination, laboratory tests (total cholesterol, LDL-, HDL-cholesterol, triglyceride, fasting blood glucose, OGTT) and cardiovascular risk assessment were carried out.Proportion of involved people who tended to follow healthy diet (determined on the basis of relevant European cardiovascular primary prevention guideline, focusing on the following parameters: total daily calorie-, fat-, cholesterol intake, fruit/vegetable- and salt consumption) was 66%. In “healthy diet” group we found more patients with normal total cholesterol, LDL-cholesterol and triglyceride, blood pressure (BP) and body mass index (BMI) levels compared to “unhealthy diet” group and this difference was significant. There was no significant difference between the quality of diet and HDL-cholesterol and glucose levels. The level of cardiovascular risk changed in line with the quality of diet significantly: among those people who tended to follow a healthy diet, the proportion of low risk individuals was higher whereas among those people who did not care the quality of food, this proportion was the opposite.Intention to follow healthy diet is an important part of cardiovascular risk mitigation policy among adult Hungarian people.
Authors:Á. Mester, E. Makó, K. Karlinger, T. Györke, and E. Márton
Alimentary factors of enterogen arthropathies were studied, in particular the early morphological detection, to prevent the disease progression by nutritional prescriptions. Authors compared the method of high resolution computed tomography (HRCT) with conventional X-ray and nuclear medicine investigations. The results showed the superiority of HRCT to detect cartilage erosions and ligamental calcifications in the sacroiliac joint and lumbar facet joint. The importance of nutritional factors is briefly discussed. The need for high quality and high quantity food of patients suffering from inflammatory bowel diseases (IBD) is well known. Elemental diet is effective for remission of IBD. Folic acid intake is extremely important. Total parenteral nutrition in acute active disease (Crohn's fistulas) has not been proved to effect IBD. Elimination of whole protein as a possible luminal factor for long term application can help, if elementary amino acids are in the diet. Eicosapentaenoic acid and docosahexaenoic acid (major components of fish oils) have beneficial effects. Polyunsaturated fatty acids in the diet can decrease the inflammation. Antioxidants, glutamine are essential in the diet. Removal of fat is effective to get remission. Alimentary complication in IBD patients can be osteoporosis, so there is a need for regular bone densitometry. Conclusion of the study suggests that HRCT offers more sensitive detection of enterogen arthropathy related changes. The predictive value of this diagnostic method is accurate enough to advise restrictive and/or supplemental diets of IBD patients. Dietary therapy allows circumvention of the adverse side-effects of repeated courses of steroids.
Authors:András Pataricza, Z Márton, Z Hegedűs, Irén Krassói, A Kun, A Varró, and J Gy Papp
Functional role of calcium-activated potassium (KCA) channels on the basal and agonist-elevated arterial tones was investigated in isolated rabbit aorta, porcine and canine coronary arteries as well as in human internal mammary artery. The vascular tones enhanced by contractile agents were increased further by preincubation of these conduit blood vessels with selective (charybdotoxin or iberiotoxin) or non-selective (tetraethylammonium) inhibitors of KCA channels. The basal tone (without an agonist) was increased only in the canine coronary artery. The results indicate a feed-back regulatory role of KCA channels counteracting the vasospasm of conduit arteries.
Authors:Cs. Horváth, J. Kis, Á. Tarnawa, K. Kassai, H. Nyárai, and Márton Jolánkai
Winter wheat (Triticum aestivum L.) yield samples taken from a consecutive series of crop years representing drought, normal and moist conditions at the Nagygombos experimental site of the Szent István University have been evaluated. The impact of N topdressing and crop year conditions on the performance of protein and wet gluten content were studied.The results suggest that ascending levels of N topdressing, and increased number of applications had a beneficial effect on the protein content, as well as on wet gluten values. Crop year had a significant effect on quality manifestation. The drier the crop year, the better the recorded quality performance. The magnitude of changes was bigger in case of gluten than in that of protein values. There were minor differences between the two varieties examined, especially in their response patterns to nitrogen supply. Dough formation depends mainly on the gliadin/ glutenin ratio, but there is less information on the agronomic and climatic impacts that may cause alterations in that.
Authors:L. Sági, M. Rakszegi, T. Spitkó, K. Mészáros, B. Németh-Kisgyörgy, A. Soltész, F. Szira, H. Ambrus, A. Mészáros, G. Galiba, A. Vágújfalvi, B. Barnabás, and L. Marton
Research with transgenic plants in the Agricultural Research Institute of the Hungarian Academy of Sciences is primarily related to applications that are essential for the genetic improvement of cereals. The two main directions are connected to wheat and maize breeding and are focused on improving agronomic and nutritional traits. This paper highlights experiments in these areas, which are conducted in national as well as international collaborations. The transparency of this work is ensured by the dissemination of information about approved confined field tests to the public via the internet.
Authors:A. Bittsánszky, G. Gyulai, R. Malone, G. Gullner, J. Kiss, M. Czakó, L. Márton, L. Heszky, and T. Kőmíves
As DNA methylation patterns are inherited (‘epigenetic memory’)
I transgenic poplar (
) clones (11
) were treated with the DNA demethylating drug DHAC (5,6-dihydro-5′-azacytidine hydrochloride) at 10
M for 7 days in order to study acquired plant molecular defense mechanisms in novel plant sources. In this study, the response of relative gene expression levels of transgene
I and poplar gene
1 to DHAC treatment were analyzed by qRT-PCR (
ranscriptase PCR). High expression levels of transgene
I were observed in the 6
clone (13.5-fold increase) compared to 11
(1.0) sample. The expression level doubled (1.8-fold increase) in the DHAC-treated 6
samples but not in the 11
clone (0.4-fold). Contrary to this, the relative copy number of transgene
I in the 6
clone was found to be 60% less (1.0) than in the 11
sample (1.6). Relative expression level of endogenous poplar gene
1 showed significantly higher responsiveness to DHAC-induced demethylation than the transgene
I with the highest expression level in the untransformed WT poplar (19.7-fold increase) compared to transformed clones of 6
(8.7-fold increase) and 11
(2.5-fold increase), respectively. Competition in the reactivation capacity between transgene
I and poplar
1 of 6
clone was also observed as the relative gene expression level of transgene
I increased from a high relative expression level (13.5) up by about twofold (1.8 times) rate (to 23.7) compared to poplar
1 gene that increased by an 8.7 increment from a lower level (1.6 rel. expression) to 13.9.
Authors:Éva Polyák, K. Gombos, B. Hajnal, K. Bonyár-Müller, Sz Szabó, A. Gubicskó-Kisbenedek, K. Marton, and I. Ember
Artificial sweeteners are widely used all over the world. They may assist in weight management, prevention of dental caries, control of blood glucose of diabetics, and also can be used to replace sugar in foods. In the animal experimentation mice were given oral doses of water solutions of table top artificial sweeteners (saccharin, cyclamate based, acesulfame-K based, and aspartame) the amount of maximum Acceptable Daily Intake (ADI) ad libitum. The controls received only tap water with the same drinking conditions as the treated groups. The mice were fed chow ad libitum.We measured food intake and body weight once a week, water and solutions of artificial sweeteners intake twice a week. The data were analysed by statistical methods (T-probe, regression analysis).Consumption of sweeteners resulted in significantly increased body weight; however, the food intake did not change.These results question the effect of non-caloric artificial sweeteners on weight-maintenance or body weight decrease.