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  • Author or Editor: A. Noujaim x
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Abstract  

Compounds of both gold and platinum are used in medicine, the former as salts to treat arthritides and the latter as the metal complex cisplatin to treat cancer. We have investigated neutron activation analysis with the Slowpoke II reactor as an assay method for both elements using human blood plasma as a matrix. Neutron activation of platinum gives rise to 3.15 day199Au while that of gold produces 2.7 day198Au. Activated samples are dissolved during heating in test tubes and the gold extracted by adding dibutyl sulphide to the same tube. The latter is formed to able to quantitate Pt down to 60 ng and Au down to 60 pg. The dissolution technique and possible interferences in the assay are discussed.

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Abstract  

Rabit anti-T (IgG) was radioiodinated by iodine monochloride using three different methods: Direct, Indirect and Protected. Although protection of antigen combining sites during radiolabelling (Protected method) did not significantly increase the binding of the rabbit anti-T to an artificial hapten, binding of the antibody to the natural antigen on the cell membrane was considerably improved when the antibody was labelled by this Protected method. We propose that radiolabelled anti-T may be useful in tumour localizing studies in man, but that binding efficiency of radiolabelled antibodies to isolated antigens may not reflect binding efficiency to cell bound antigens.

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