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Abstract

Adenosine (ADO) and endothelin-1 (ET-1) play an important role in the regulation of myocardial functions. The pericardial fluid accumulates these regulatory agents and reflects well their levels in the myocardial interstitium. The aim was to investigate the interaction and cardiovascular effects of ADO and ET-1 evoked from the pericardial space, determine the pericardial elimination of intrapericardially applied adenosine and its first metabolite, inosine (INO) and observe their effects on the cardiovascular function compared to their intravenous administration. The present studies were performed on in situ dog heart using the closed pericardium model. Significant increase of the pericardial concentrations of adenine nucleosides (adenosine and inosine) after intrapericardial administration of ET-1 has been found. Regarding the adenine nucleosides-ET-1 interaction, we have demonstrated ET-1 liberation after intrapericardial administration of adenine nucleosides. The present study confirmed significantly slower elimination of adenine nucleosides in the pericardial space than in the systemic circulation. In conclusion, characteristic cardiovascular effect and bidirectional interaction of adenine nucleosides and ET-1 could be provoked by and detected in the pericardial space, reflecting parallel changes in the myocardial interstitium. The low pericardial turnover rate of adenine nucleosides may offer the opportunity of utilizing their multiple beneficial effects for local pharmaco-therapeutic interventions.

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Abstract

The hegemony of the Western higher education institutions in the global university market is being challenged by China. The top Chinese universities have significantly improved their international ranking positions. When it comes, however, to the ability of universities to attract foreign students and faculty, the Chinese higher education institutions' performance raises questions. The International Outlook scores of these universities, although showing an increasing trend, are still lacking behind the U.S. or Western European top universities. China is primarily a student ‘exporter.’ It also became a leading destination country for students from Asia or Africa, but it is still far from reaching the ‘international openness’ level of the U.S. or the UK universities. The publication networks of the top Chinese higher education institutions indicate that these universities prefer to publish with other Chinese institutions or the U.S. universities.

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Absztrakt:

Az emberi szájüreg mikroorganizmusok milliárdjainak élőhelye. A legnagyobb arányban baktériumok vannak jelen, több mint 600 baktériumfaj izolálható. Nagy részük ártalmatlan, némelyik kifejezetten hasznos, azonban nem megfelelő szájhigiénia, illetve legyengült immunstatus esetén számos lágy- és keményszöveti megbetegedést okozhatnak, melyeknek sok esetben szisztémás következményeik lehetnek. A szájüreg leggyakoribb bakteriális megbetegedésének tekinthető a fogszuvasodás és a fogágybetegség. Mindkét esetben elsődleges kóroki szerepe van a nem megfelelő szájhigiénia következtében kialakult dentális biofilmnek. A fogszuvasodás kórfolyamatában a Streptococcus mutans, a S. sanguinis, a S. viscosus és a Lactobacillus acidophilus játszik főszerepet, súlyos fogágybetegség esetén viszont az anaerob parodontopathogen kórokozók jellemzők, úgymint Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Bacteroides forsythus, Prevotella intermedia, Fusobacterium nucleatum, Campylobacter rectus. A kezeletlen fogszuvasodás a fogbél elhalásához vezet, s ez a fogágy irányába terjedő gyulladást okoz, amely gócnak tekintendő. A kezeletlen fogágybetegség esetén csonttasakok keletkeznek, melyek szintén gócnak minősülnek. A fogászati gócoknak számos szisztémás következményük lehet, úgymint szív-ér rendszeri megbetegedések, cukorbetegség, tüdőgyulladás, ízületi gyulladás, koraszülés, foltos hajhullás. Ezen betegségek esetén mindenképpen gondolni kell fogászati gócra. A tervezett műtétek előtti professzionális plakk-kontroll és klórhexidines öblögetés kiemelkedő jelentőséggel bír az aspirációs pneumonia prevenciójában. A szájüregi daganatok multikauzálisak; egyre több kutatócsoport vizsgálja az egyes baktériumok szerepét a szájüregi daganatok karcinogenezisében. Az említett kórképeken kívül a viszonylag ritka, ámde sokféle formában megjelenő, gyakran diagnosztikai kihívást jelentő bakteriális lágyrész-betegségek bemutatását egy következő közleményben tervezzük. Orv Hetil. 2019; 160(19): 739–746.

Open access
Acta Oeconomica
Authors:
Adrian Fanaca
,
Joseph Larsen
, and
Andrea Nagy
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Abstract

COVID-19 has been the “hottest” topic in many fields of research during 2020–2021. Our analysis focuses on the publications related to the pandemic in the business and economics area. Using the Web of Science database, the main international research patterns in this field have been analysed. Our research covers less than two years (2020 and part of 2021), but the number of publications is large (more than 1,000) in this limited time span. The publication patterns of the CEE countries have also been examined. Bibliometric and social network analysis was used to assess which countries and institutions published the most during this period. For analysing the main trends in the given field, keyword analysis was performed.

Open access

Demodex mites are ectoparasites often found in follicles of facial skin. Their role in human diseases is under investigation, and a growing number of studies indicated that they contribute to chronic inflammatory conditions of the skin, such as rosacea, blepharitis, otitis externa, alopecia and folliculitis. In our study we tested 96 healthy adults for the presence of Demodex mites. Risk factors influencing presence of mites and skin types of the tested individuals were evaluated. We found Demodex folliculorum or Demodex brevis in 17.7% of the samples, more frequently in males (21.9%) and in older adults (20%). Use of make-up seems to reduce the likelihood of Demodex carriage, while pet ownership, use of shared items and living in close contact with older adults had no significant influence of presence of mites. Demodex positive individuals described their skin to be drier, more prone to erythema, but less for folliculitis compared to Demodex negative subjects.

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