The uptake of persistent organic pollutants (POPs) from soil by plants allows the development of phytoremediation protocols to rehabilitate contaminated areas. In this study theoretical descriptors have been employed as independent variables for developing quantitative structure-activity relationship (QSAR) models for predicting the bioconcentration factors (BCFs) of POPs in different plants. A quantitative estimation has been given on the molecular properties of POPs in terms of theoretical molecular descriptors that are relevant to the uptake from soil and pharmacokinetic behavior in plants. The study resulted in statistically significant linear regression models developed for the BCF values of 20 polychlorinated dibenzo-p-dioxins/dibenzofurans and 14 polyhalogenated biphenyls in two zucchini varieties based on retrospective data. The parameters have been selected from a set of 1660 DRAGON, 150 VolSurf and 11 Quantum Chemical descriptors. The best regression model (Eq. 1), employing VolSurf, DRAGON GETAWAY and quantum chemical descriptors, displayed the following highly significant statistical parameters: n=27, R2=0.940, SE=0.155, F=392.1, q2=0.922; external validation set: n=7, R2=0.739, q2=0.47, SE=0.338, F=14.2 It is suggested that the QSAR models proposed might contribute to the development of workable soil remediation strategies.
Authors:B Borda, T Németh, A Ottlakan, C Keresztes, É Kemény and G Lázár
Despite an increase in the number of cadaver donors and overall organ transplantations, the dramatic increase in the waiting list makes it necessary to reconsider donor criteria. The authors wanted to examine whether differences could exist in the function and/or morphology of transplanted kidneys originated from expanded criteria donors (ECDs) and ideal donors 1 and 5 years after transplantation.
Kidney function and histopathologic findings were analyzed and compared 1 and 5 years after transplantation in 97 patients having ECD kidneys and in 178 patients who received ideal donor kidneys (IDK).
Serum creatinine level was significantly higher (p = 0.001) and estimated glomerular filtration rate was significantly lower (p = 0.003) in patients having ECD kidneys as compared with those with IDK 5 years after transplantation. Morphological changes in the transplanted kidneys, such as tubulitis (p = 0.025) and interstitial inflammation (p = 0.002), were significantly more frequently present in patients with ECD kidneys than in those with IDK 1 year after transplantation.
Despite an absence of differences in kidney function 1 year after kidney transplantation between patients having ECD and IDK, morphological differences in the transplanted kidneys can be detected between the two groups of patients.