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Journal of Flow Chemistry
Authors: Alex D. Martin, Ali R. Siamaki, Katherine Belecki and B. Frank Gupton

A highly efficient continuous synthesis has been developed for telmisartan, the active ingredient in the antihypertensive drug, Micardis. This synthetic route employs a convergent strategy that requires no intermediate purifications or solvent exchanges. The key step in the reaction scheme is a Suzuki cross-coupling reaction between two functionalized benzimidazoles that is catalyzed by a solid-supported Pd catalyst. This flow-based approach utilizes a tubular reactor system coupled with a plug flow packed bed cartridge unit that produces telmisartan in an 81% isolated yield.

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Journal of Flow Chemistry
Authors: L. Zane Miller, Jeremy L. Steinbacher, Tania I. Houjeiry, Ashley R. Longstreet, Kendra L. Woodberry, B. Frank Gupton, Banghao Chen, Ron Clark and D. Tyler McQuade

Abstract

Monodisperse silica microcapsules are typically fabricated using hard templating methods. Though soft templating methods are known, none yet provides a fast and easy method to produce monodisperse capsules. Herein, we describe a mesofluidic strategy whereby monodisperse droplets of reactive silica precursors are formed using a snap-off mechanism via a T junction. Both the mesofluidic system and the composition of the reactive silica formulation are critical features. Using solid- and solution-state 29Si nuclear magnetic resonance, scanning electron microscopy, and optical microscopy, we have developed models for why some formulations form exploding capsules, why some capsules contain crystalline materials, and why some capsules have thin or thick walls.

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