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  • Author or Editor: B. M. Gupta x
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Abstract  

The objective of this paper is to suggest a methodology for studying the quantitative profile of a research university, with a view to get idea about the performance and impact of research produced in each department, and the comparison of the impact of research in various departments.

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Abstract

This study analyses the research output of Nepal in S&T during 2001–10 on several parameters including its growth and country publications share in the world's research output, country publications share in various subjects in the national and global context, pattern of research communication in core domestic and international journals, geographical distribution of publications, share of international collaborative publications at the national level as well as across subjects and characteristics of high productivity institutions, authors and cited papers. The Scopus Citation Database has been used to retrieve the publication data for 10 years.

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Abstract

The research output of India in computer science during 1999–2008 is analyzed in this paper on several parameters including total research output, its growth, rank and global publication share, citation impact, share of international collaborative papers and major collaborative partner countries and patterns of research communication in most productive journals. It also analyses the characteristics of most productive institutions, authors and high-cited papers. The publications output and impact of India is also compared with China, South Korea, Taiwan and Brazil.

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Abstract  

The study analyses the distribution of productivity of authors in theoretical population genetics (TPG) as reflected in their publication output from 1881 to 1980 from two different approaches. The internal dynamics of TPG specialty affecting the distribution of the productivity of authors is studied using time cross-sectional type of approach. Here the productivity distribution of authors in 10 time-year blocks and in three phases of the development (1921-50, 1951-65 and 1966-80) of TPG is studied using cohort type of approach. The extent of cumulative advantage acquired by the prolific group of authors over time in TPG is also studied. The paper also analyzes the regularity in the distribution of productivity of various cohorts, having same length of activity, but different periods of participation.

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Authors: B.M. Gupta, Suresh Kumar, S. Sangam and C.R. Karisiddappa

Abstract  

The main objectives of this study are: (a) to find the applicability of selected growth models to the growth of publications in six sub-disciplines of social sciences, namely anthropology, economics, history, political science, psychology, and sociology in the world; and (b) to verify the criteria for selecting the most appropriate growth model suggested by Eggheand Rao (1992).

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Abstract  

The paper aims to investigate cytogenetic and apoptotic responses of γ-irradiation in a radio-resistant cell strain designated as M5. Induced micronuclei, chromosomal aberrations, nuclear fragmentation and nucleosomal ladders by γ-irradiation were less at equal doses in M5 cells in comparison with that obtained in the parental Chinese hamster V79 cells. However, at equal survival, there were no differences in the end points studied. Results indicate that the residual damages that lead to reproductive cell death also resulted in the cytogenetic and apoptotic responses. We speculate that the repair efficiency in M5 cells was more efficient and increased DNA repair could be the cause of radiation resistance observed in M5 cells.

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Authors: K. C. Garg, B. M. Gupta, Tabassum Jamal, Santanu Roy and Suresh Kumar

Summary An analysis of 330 questionnaires received from project investigators funded by AICTE indicates that project investigators preferred to present their research results at conferences rather than in national and international journals. Impact of funding has been better on human resource capability development as compared to research and technological output. Analysis of data using data envelopment analysis indicates that projects funded under electronics and communication engineering, mechanical engineering, electrical engineering and management displayed some consistency and uniformity with regard to impact on various output parameters.

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Authors: N. K. Satti, M. Amina, P. Dutt, V. K. Sharma, P. Sharma, I. Khan, B. D. Gupta, K. A. Suri, S. C. Sharma, R. K. Johri and S. N. Sharma

Summary

In this paper we describe a sensitive and reproducible reversed-phase high-performance liquid chromatography (HPLC) method with photodiode-array detection for isolation and quantification of the bioactive hydrophilic constituent 7-(1-O-β-d-galacturonide-4′-(1-O-β-d-glucopyranosyl)-3′,4′,5,7-tetrahydroxyflavone, 1, from the seeds of Cuminum cyminum. Compound 1 was separated isocratically on a C18 preparative column, in high purity, after removal of solvents. The purity and identity of the compound were established by use of LC-mass spectrometry and by spectroscopic techniques (1H and 13C NMR). The purity of 1 was also confirmed by HPTLC.

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Authors: E. Sapi, K. Balasubramanian, A. Poruri, J. S. Maghsoudlou, K. M. Socarras, A. V. Timmaraju, K. R. Filush, K. Gupta, S. Shaikh, P. A. S. Theophilus, D. F. Luecke, A. MacDonald and B. Zelger

Lyme borreliosis, caused by the spirochete Borrelia burgdorferi sensu lato, has grown into a major public health problem. We recently identified a novel morphological form of B. burgdorferi, called biofilm, a structure that is well known to be highly resistant to antibiotics. However, there is no evidence of the existence of Borrelia biofilm in vivo; therefore, the main goal of this study was to determine the presence of Borrelia biofilm in infected human skin tissues. Archived skin biopsy tissues from borrelial lymphocytomas (BL) were reexamined for the presence of B. burgdorferi sensu lato using Borrelia-specific immunohistochemical staining (IHC), fluorescent in situ hybridization, combined fluorescent in situ hybridization (FISH)–IHC, polymerase chain reaction (PCR), and fluorescent and atomic force microscopy methods. Our morphological and histological analyses showed that significant amounts of Borrelia-positive spirochetes and aggregates exist in the BL tissues. Analyzing structures positive for Borrelia showed that aggregates, but not spirochetes, expressed biofilm markers such as protective layers of different mucopolysaccharides, especially alginate. Atomic force microscopy revealed additional hallmark biofilm features of the Borrelia/alginate-positive aggregates such as inside channels and surface protrusions. In summary, this is the first study that demonstrates the presence of Borrelia biofilm in human infected skin tissues.

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