Search Results

You are looking at 1 - 2 of 2 items for

  • Author or Editor: B. Noll x
  • Refine by Access: All Content x
Clear All Modify Search

Abstract  

The coupling of Re- and99mTc-MAG3 complexes with amines and nucleobases was carried out with good yields using O-(benzotriazol-1-yl-)-N,N,N',N'-tetramethyl-uronium-tetrafluoroborate (TBTU), and base in polar aprotic solvents (NMP, DMF, DMSO). The one step reaction followed by simple gel chromatography makes the method well appropriate for preparations at the low no-carrier-added level of technetium-99m.

Restricted access

Abstract  

The Tc budget in several ROTOP-generators was determined by neutron activation analysis (NAA) and UV-spectroscopy. The complete procedure included the preparation of the generator, elution cycle in 24 to 72 h intervals and evaporation of the eluates to dryness. The samples were aliquoted, irradiated in the reactor and analyzed via99Tc(n, n')99mTc 99Tc reaction as well as by UV-absorption due to pertechnetate. The most reliable method proved to be NAA including chemical separation from24Na by ion exchange after the complete decay of38Cl. The detection limit was 50 ppb (3 ng Tc), compared with the total amount of several 10–5 g down to 10–7 g Tc in the system and its fractions. The mass balance and the elution profiles obtained correspond very well to the theoretical values. The results permit further quantitative considerations on both elution kinetics and the generator system.

Restricted access