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Hungarian Medical Journal
Authors: Oche O. Agbaji, Nimzing G. Ladep, Patricia Agaba, Bitrus P. Badung, Monday L. Danung, Godwin Imade, John A. Idoko, Rob Murphy, and Phyllis Kanki

Background: There is a rising trend of hepatitis B co-infection among HIV positive individuals and this may negatively impact their morbidity and mortality. This study analyzed HBsAg prevalence, its demographic distribution and relationship to the immunological and viral load status of HIV positive cohort in Jos. Methods: This was a cross-sectional study conducted at the antiretroviral treatment centre in Jos between August 2004 and April 2005. Biodata of 1042 consenting HIV positive patients were obtained. Blood samples obtained from them were tested for hepatitis B surface antigen by Enzyme Linked Immunosorbent Assay. CD4 cell count was done by flow cytometry (Partec, Germany) and viral load by PCR techniques (Roche Amplicor 1.5). The data obtained were analyzed using Epi Info 2004 statistical software. Results: One hundred and sixty seven (16%) of the 1042 patients were reactive to HBsAg. Thirteen (22.4%) of 58 divorced patients had the highest co-infection rate. Ninety-seven (14.2%) out of 681 females were co-infected with hepatitis B, while seventy (19.4%) out of 361 males had the co-infection. Most of the patients at the AIDS stage of the HIV infection were co-infected with hepatitis B. The median HIV viral load of HBsAg-positive patients was higher than that of non-HBV co-infected patients. Conclusion: This study showed a high HBsAg prevalence among our patients with a significant male preponderance. This may have a negative impact on the CD4 recovery and viral load reduction of the patients on treatment.

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