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  • Author or Editor: Bruna B. Casanova x
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Studies on the continuous-flow synthesis of nonpeptidal bis-tetrahydrofuran moiety of Darunavir

Journal of Flow Chemistry
Volume/Issue:
Volume 5: Issue 4
DOI:
https://doi.org/10.1556/1846.2015.00031
Authors: Raquel A. C. Leão, Raquel de O. Lopes, Marco A. de M. Bezerra, Mauro N. Muniz, Bruna B. Casanova, Simone C. B. Gnoatto, Grace Gosmann, Laszlo Kocsis, Rodrigo O.M.A. de Souza, and Leandro S. de M. Miranda

The use of continuous-flow chemistry has shown to be an important tool in improving API manufacture. In the present paper, we report the use of continuous-flow reactors in the synthesis of the bicyclic side chain of antiretroviral Darunavir.

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