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- Author or Editor: Chao Ren x
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Abstract
At present, many great Chinese cities are undergoing changes in urban development models, from focusing on speed construction to quality construction. People pay more attention to the improvement of construction quality, from the perspectives of culture, spirit, urban image and function optimization.
The creation of place scripts is an important method of modern urban space, and in specific place to design, deepen, and arrange certain procedures and content, so that people can experience different feelings, learn more stories, or cultivates sentiment through various experiences, inherit diverse memories. This paper is based on design projects to analyze research and build place scripts to summarize the expressions that shape memory.
Slow tourism, a sustainable tourism pattern gradually emphasized over the past years, stresses on experiencing tourism campaigns with slow and recreational attitudes to create value for life and enhance well-being. Although the concept of slow tourism presents certain consensus in academic studies, it still encounters a lot of operational challenges, which could be properly solved through the educational training of operators and consumers and the economic value chain formed by industry alliances. In terms of the practical operation, the slow tourism promotion architecture is developed for promoting slow tourism in Green Island, Taiwan. The architecture is divided into two stages. The preparation stage focuses on communication, training, and the improvement of industrial environment to form the slow tourism industry alliance for cross-selling and importing visitors. The operational stage tends to form the overall image of the destination by maintaining the quality of slow tourism through review and innovation and gradually extend the slow tourism industry alliance. The key role in the promotion architecture is local intermediary organizations which integrate internal and external resources to have slow tourism present the maximal benefits.
Abstract
With the development of society and economy, people pay more and more attention to thematic landscape architectural design featuring various cultures. Landscape architectural design is no longer only satisfied with the standardized, identical design style, but should focus on some specific cultural communication functions. In the thematic landscape architectural design, the use of cultural symbols can reflect the characteristics of the park. Through some research and practical design, the design method of using cultural symbols in landscape architectural design is summarized: from finding cultural elements to design language transformation.
Abstract
With the gradual improvement of urban construction, more and more experts and the public realized that the speed of urban development be reasonable, which caused urban regeneration to turn to a new-minded “urban micro-regeneration”. “Micro-regeneration” is an extension of the concept to the direction of urban construction. The concept of micro-regeneration was first applied to the regeneration of individual buildings in the old city. The research on the intervention of public art in urban micro-regeneration is still in its infancy in China. Based on practice, this paper explores the possibility of public art's intervention in urban micro-regeneration.
The effect of 2,4,6-trimethyl-N-(meta-3-trifluoromethyl-phenyl)-benzenesulfonamide (m-3M3FBS), a presumed phospholipase C activator, on cytosolic free Ca2+ concentrations ([Ca2+]i) in OC2 human oral cancer cells is unclear. This study explored whether m-3M3FBS changed basal [Ca2+]i levels in suspended OC2 cells by using fura-2 as a Ca2+-sensitive fluorescent dye. M-3M3FBS at concentrations between 10–60 μM increased [Ca2+]i in a concentration-dependent manner. The Ca2+ signal was reduced partly by removing extracellular Ca2+. M-3M3FBS-induced Ca2+ influx was inhibited by the store-operated Ca2+ channel blockers nifedipine, econazole and SK&F96365, and by the phospholipase A2 inhibitor aristolochic acid. In Ca2+-free medium, 30 μM m-3M3FBS pretreatment inhibited the [Ca2+]i rise induced by the endoplasmic reticulum Ca2+ pump inhibitors thapsigargin and 2,5-di-tert-butylhydroquinone (BHQ). Conversely, pretreatment with thapsigargin, BHQ or cyclopiazonic acid partly reduced m-3M3FBS-induced [Ca2+]i rise. Inhibition of inositol 1,4,5-trisphosphate formation with U73122 did not alter m-3M3FBS-induced [Ca2+]i rise. At concentrations between 5 and 100 μM m-3M3FBS killed cells in a concentration-dependent manner. The cytotoxic effect of m-3M3FBS was not reversed by prechelating cytosolic Ca2+ with 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA). Propidium iodide staining data suggest that m-3M3FBS (20 or 50 μM) induced apoptosis in a Ca2+-independent manner. Collectively, in OC2 cells, m-3M3FBS induced [Ca2+]i rise by causing inositol 1,4,5-trisphosphate-independent Ca2+ release from the endoplasmic reticulum and Ca2+ influx via phospholipase A2-sensitive store-operated Ca2+ channels. M-3M3FBS also induced Ca2+-independent cell death and apoptosis.
