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Abstract

Curcumin (CUR), a frequently-used food additive and flavorings, has been reported to be safe at a wide dose range. Bacillus subtilis (B. subtilis) is commonly found in soil and decomposing organic matter, and it was reported beneficial for humans when ingested. Up to now, there have been no contraindication of B. subtilis except for the avoidance of the drug combination with antibiotics, and the interaction of food and B. subtilis drug is blank. In this study, the interaction of CUR and B. subtilis was investigated. Microcalorimetry was applied to evaluate the effect of CUR on B. subtilis growth. By analyzing the main parameters extracted from the heat-flow power–time curves, it was concluded that CUR could inhibit the growth of B. subtilis, and the 50% inhibiting concentration (IC50) valued 109.9 μg mL−1. The results revealed that it is unreasonable to take CUR and B. subtilis at the same time, and it also provided a new way for the investigation of the interaction between food and drug. Meanwhile, this study indicated that the safety of CUR should be re-evaluated.

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Abstract  

Twenty clinical scale alumina-based 188W/188Re generators and carrier-free 188Re has been produced at the Institute of Nuclear Energy Research (INER-Taiwan) for over ten years. 2845.6 GBq (76.9 Ci) of 188Re-perrhenate solution has been eluted from generators during the past ten years. We have used the harvesting 188Re solution for labeling radiopharmaceuticals, such as 188Re-HEDP, 188Re-MDP, 188Re-microsphere, 188Re-lipiodol, and 188Re-sulfur colloid, etc. The average eluting yield of 188Re is 78.6±5.8% that was investigated at 1115 harvesting times from 20 generators. Each generator can be used more than six months but the Millipore needs to be changed every two months for smooth harvesting and high yield of 188Re solution.

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Abstract  

Two procedures are described for fast separations of berkelium from complex mixtures of reaction products arising from heavy ion reactions, such as18O+248Cm. The first procedure uses a combination of several extraction steps with a final separation on a cation exchanger, the second procedure starts with an anion exchange column which is followed by multiple extractions in different media. The elements separated in the different steps were analyzed and overall decontamination factors are given.

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Journal of Radioanalytical and Nuclear Chemistry
Authors: Zhang Shuyan, Wang Xizhong, Wang Zishu, Cheng Wenyuan, Jin Jianan, Zhang Jiazao, Xu Daoquan, Shao Yuesheng, Luo Changrong, Wang Juan, Wu Kejia, and Zhou Maolun

Abstract  

Na2 1 1At and2 1 1At–Te colloid injections were prepared. By comparison with tissue distribution of Na2 1 1At and2 1 1At–Te colloid injections it has been demonstrated that the2 1 1At–Te colloid is stable in vivo. It has been shown that the radiohalogen,2 1 1At, has huge and extensive radiobiological effects in studying on the changes in histopathology, enzyme histochemistry, chromosome aberration, micronucleus frequency of bone-marrow polychromatic erythrocytes and the injury effect of2 1 1At on experimental Ehrlich ascites cells.

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Journal of Thermal Analysis and Calorimetry
Authors: Xingfeng Li, Cheng Jin, Wei Liu, Jian Zhou, Weijun Kong, Bing Dai, Jiabo Wang, Dan Yan, Yanling Zhao, Yun Luo, and Xiaohe Xiao

Abstract

Using microcalorimetry, the characteristic metabolic heat flow power-time curves of S. aureus growth affected by Ursodesoxycholic acid and Hyodeoxycholic acid were measured at 37 °C. The thermal-kinetic parameters such as, growth rate constant k, the maximum power output (P m), the time corresponding to the maximum power output (t p), total heat-production Q t, half inhibitory concentration of the drugs (IC 50) were calculated from the growth curves. For both HDCA and UDCA, with the increasing of concentration, k, P m, and Q t decreased, meanwhile, kc fit a linear equation, t p was prolonged correspondingly. Principle component analysis, the results indicated t p might be the main parameter in evaluating the antibacterial activity of HDCA and UDCA in microcalorimetric method. Combining with t p and IC 50, the results revealed that the differences and trends of antibacterial activity of these bile acid derivatives were: HDCA > UDCA. Structure-activity relationship (SAR) analysis showed that the α-OH at C-3 and C-6 position at equal pace on the steroid nucleus enhanced the hydrophilicity of HDCA, which led to a stronger antibacterial effect than UDCA. In this study, a useful tool was provided to accurately evaluate the antibacterial effects of bile acid derivatives. The thermolysis curve recorded by microcalorimetry could provide a lot of kinetic and thermodynamic information for the study of growth process of living microbial, which could be helpful in the screening of high efficacy antibacterial agents.

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Journal of Behavioral Addictions
Authors: Tao Luo, Lixia Qin, Limei Cheng, Sheng Wang, Zijun Zhu, Jiabing Xu, Haibo Chen, Qiaosheng Liu, Maorong Hu, Jianqin Tong, Wei Hao, Bo Wei, and Yanhui Liao

Abstract

Objective

Social media disorder (SMD) is an increasing problem, especially in adolescents. The lack of a consensual classification for SMD hinders the further development of the research field. The six components of Griffiths’ biopsychosocial model of addiction have been the most widely used criteria to assess and diagnosis SMD. The Bergen social media addiction scale (BSMAS) based on Griffiths’ six criteria is a widely used instrument to assess the symptoms and prevalence of SMD in populations. This study aims to: (1) determine the optimal cut-off point for the BSMAS to identify SMD among Chinese adolescents, and (2) evaluate the contribution of specific criteria to the diagnosis of SMD.

Method

Structured diagnostic interviews in a clinical sample (n = 252) were performed to determine the optimal clinical cut-off point for the BSMAS. The BSMAS was further used to investigate SMD in a community sample of 21,375 adolescents.

Results

The BSMAS score of 24 was determined as the best cut-off score based on the gold standards of clinical diagnosis. The estimated 12-month prevalence of SMD among Chinese adolescents was 3.5%. According to conditional inference trees analysis, the criteria “mood modification”, “conflict”, “withdrawal”, and “relapse” showed the higher predictive power for SMD diagnosis.

Conclusions

Results suggest that a BSMAS score of 24 is the optimal clinical cut-off score for future research that measure SMD and its impact on health among adolescents. Furthermore, criteria of “mood modification”, “conflict”, “withdrawal”, and “relapse” are the most relevant to the diagnosis of SMA in Chinese adolescents.

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