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Journal of Flow Chemistry
Authors: Aiichiro Nagaki, Yusuke Takahashi, Shigeyuki Yamada, Chika Matsuo, Suguru Haraki, Yuya Moriwaki, Songhee Kim and Jun-ichi Yoshida

Abstract

Vinyllithiums were effectively generated by bromine–lithium exchange reaction of vinyl bromides with one eq of s-BuLi in a flow microreactor system at 0 °C or 20 °C, although two eq of t-BuLi and much lower temperatures are required for a conventional macro batch reaction. Subsequent reactions with various electrophiles in the flow microreactor system gave the corresponding vinyl compounds in good yields.

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