Authors:Mohamadreza Bakht, Mahdi Sadeghi, and Claudio Tenreiro
Application of nanoparticles in nuclear medicine has aimed to develop diagnosis and therapeutic techniques. Cerium oxide nanoparticles
(CNPs) are expected to be useful for protection of healthy tissue from radiation-induced harm and could serve therapeutic
function. Among a variety of cerium radioisotopes, 137mCe (T1/2 = 34.4 h, IT (99.22%), β+ (0.779%)) could be a novel candidate radionuclide in the field of diagnosis owing to its appropriate half-life, 99.91% natural
abundance of target and its intense gamma line at 254.29 keV. In this study, 137mCe excitation function via the natLa(p,3n) reaction was calculated by TALYS-1.2 and EMPIRE-3 codes. The excitation function calculations demonstrated that the
natLa(p,3n)137mCe reaction leads to the formation of the 136/138Ce isotopic contamination in the 22–35 MeV energy range. Interestingly, the isotopic impurities of 137mCe could serve radio protector function. Overall results indicate that the cyclotron produced 137mCeO2 nanoparticles by irradiation of a target encompassing lanthanum oxide nanoparticles could be a potent alternative for conventional
diagnostic radionuclides with simultaneous radioprotection capacity.
Authors:Mahdi Sadeghi, Omid Kiavar, S. Hosseini, Rozhin Fatehi, and Claudio Tenreiro
The Nitinol stent was bombarded in a cyclotron at a flux rate of 4 μA/cm2 to produce 48V via 48Ti (p, n) 48V reaction. In this study dose distribution of 48V radioactive stent was investigated for renal arteries. Version X-2.6 of the MCNP Monte Carlo radiation transport system
code was employed to calculate dose distribution around the stent. As 48V is a mixed gamma and beta particle emitter, two separate runs of MCNP for both beta and gamma particles were performed and
the total deposited dose was acquired by adding the two mentioned values. In order to verify the simulation, the calculated
results have been compared with previous published data for the source. Calculated results show high dose gradient near the
stent and the maximum amount of dose deposits at the vessel wall. According to (AAPM) TG-60/149 protocol, the dosimetric parameters,
including geometry function, G(ρ,z), radial dose function, gL(ρ), and anisotropy function, F(ρ,z), were also determined.
Authors:Mahdi Sadeghi, Milad Enferadi, Hojjat Nadi, and Claudio Tenreiro
Amongst the various radioisotopes of molybdenum, 93mMo in its no-carrier added form might be a potential candidate radionuclide in the field of nuclear medicine due to its suitable
half-life (T1/2 = 6.85 h) and for its intense gamma line at 263.14 keV. Aim of the presented study is to compare the calculated cross sections
for the production of 93mMo incident proton energy up to 30 MeV, theoretical calculation of production yield and calculation of target thickness requirement.
Also, deposition of 93NbO2 on Cu substrate was carried out via two special sedimentation methods for the production of 93mMo and a simple and selective extraction of molybdenum was described.