Authors:Ferenc Köteles, Dániel Fodor, Cziboly Ádám Cziboly, and György Bárdos
szerzők sorra veszik a placebo terápiás felhasználása mellett, illetve ellen
szóló különböző nézetrendszereket, érveket és implicit hiedelmeket. Áttekintik
és értékelik az eddig született kutatási eredm__
Authors:Ferenc Köteles, Dániel Fodor, Ádám Cziboly, and György Bárdos
A considerable proportion of the total effect of a drug can be due to non-specific effects. Important sources of such effects are the expectations evoked by the look-and-feel of the curatives. In this study the origin of these expectations was examined. 109 female university students completed two paper-and-pencil tests about expected connections among look-and-feel of curatives and their effects, and about personal drug experiences. Significant preferences in perceptual characteristics were found in 10 drug effects out of 19. In 5 cases out of the 10 preferred tablets, the preferences were partly explainable by previous experiences of participants. Although direct learning as a source of tablet colour preferences is an obvious assumption, there has not been any research in this area. Possible consequences of changing drug expectations by direct learning are discussed and several health psychological conclusions are drawn.
Authors:Dániel J. Kócsó, Judit Szabó-Fodor, Miklós Mézes, Krisztián Balogh, Szilamér Ferenczi, András Szabó, Brigitta Bóta, and Melinda Kovács
The objective of this experiment was to determine whether fumonisin B1 (FB1) added to the diet of rats in a dose of 50 mg/kg changes the production of heat shock protein 70 (Hsp70) in the lungs and kidney of rats. We also studied the effect of this mycotoxin on the antioxidant system of the body. Mature (8 weeks old) male Wistar Crl:WI BR rats (n = 6/group) were fed the toxin-containing diet for 5 days. FB1 resulted in a 7% body weight reduction without significantly changing the feed intake. Western blot analysis of the lungs and kidney demonstrated a substantial (1.4-fold and 1.8-fold, respectively) increase in Hsp70 expression. Alterations could not be detected in the clinical chemical parameters (total protein, albumin, total cholesterol, glucose, creatinine and urea concentrations, and aspartate aminotransferase activity). There was no statistically significant change in malondialdehyde concentrations and the measured antioxidant parameters (the amount of reduced glutathione, GSH and glutathione peroxidase activity, GPx) in the blood plasma, lung and kidney tissue. Thus, it can be concluded that FB1 did not induce oxidative stress in the lungs and kidney, but increased Hsp70 production.