An accurate knowledge of the ratio Ca/P in bone biopsies is very useful in the diagnosis of osteoporosis. Similarly, measurements
on muscle biopsies are important in understanding the disturbance of intracellular fluid and electrolyte (Na, Cl, K and P)
balance in patients with metabolic myopathies (muscle diseases) and acid-base disturbances including renal failure. The ratio
Ca/P in normal subjects was found to be 2.30. Similarly, the ratio K/P was found to be very nearly constant in normal subjects.
Authors:T. Spinks, D. Bewley, A. Ranicar, and G. Joplin
The irregular shape of the human body and the non-uniformity of distribution of elements within the body makes absolute quantitation
using in-vivo neutron activation relatively difficult. However, if the mass of an element can be assessed with reasonable
accuracy, then a single measurement of a patient could reveal how far body content varied from normal. The determination of
total body calcium is of importance in the study of bone disease. We have assessed the accuracy of measuring this quantity
by varying the size of phantoms used for calibration and the distribution of element within these phantoms.