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  • Author or Editor: Dan Qiu x
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Background and aims

Few studies have tested the underlying mechanisms in the association between workaholism and depression. This study aims to investigate the potential mediation effects of work-life balance stress and chronic fatigue and depression among Chinese male workers in Hong Kong.


A population-based study among male workers in Hong Kong (n =  1,352) was conducted. The self-reported scales of assessing workaholism, work-life balance stress, chronic fatigue and depressive symptoms were included in the questionnaire. Path analysis was conducted to test the proposed mediation model.


Workaholism was directly and indirectly associated with depression through work-life balance stress and chronic fatigue, respectively. The association between work-life balance stress and chronic fatigue was statistically significant in the correlation analysis but not in the path analysis. As high as 30.5% of the participants were classified as having probable chronic fatigue, while 8.4% of the participants were classified as having probable depression.


Workaholism is a stressor that may induce negative consequences on well-being and health among male workers in Hong Kong. Interventions to help workers with time and stress management and fatigue reduction may be beneficial for their mental health. Theoretical and practical implications are discussed.

Open access

Detection of microorganisms in different growth states based on microcalorimetry

A challenging test for establishing a rapid and reliable sterility method

Authors: Manrong Tan, Yongsheng Ren, Dan Yan, Xianghong Meng, Longhu Chen, Lingling Qiu, Yan Yan, Jianyu Li and Xiaohe Xiao


A challenging method for sterility test which was rapid and reliable had been established to assess the adaptability and robustness of the microbial under different conditions. There were material and energy metabolism or exchange with microbial on microcalorimetry, as a result this method can be served as one of the optimization of thermodynamics sterility test. Thermal power-time curves under various environmental conditions (including processing temperature, storage time, and drugs inhibition) were determined. Typical microbial growth thermal power-time curves were obtained. The curves were analyzed qualitatively and quantitatively by similarity values of bio-profiles and thermodynamics parameters, such as the exponential growth rate constant (k), detection time (T d). The similarity showed that microbial growth curves of low processing temperature, short storage time (1 month), and Traditional Chinese Medicine injection (Shuanghuanglian, contained native compounds) inhibiting were match better with the normal than other circumstance. Thermodynamic parameters indicated that the microcalorimetric method could detect the positive bacteria within 18 h (less than 10 cfu), and more quickly identify the different states of the bacterium growth and metabolism than routine sterility. In conclusion, characterized by of the specific and strong two-dimensional information, microcalorimetry could supply thermograms as biological profiles to describe the microbial activity under different conditions, which were not only used as a rapid and reliable identification of microbial, but also as a method for sterility test of microcalorimetry optimization.

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