Authors:János Peti-Peterdi, L. Navar, P. Darwin Bell, D. Casellas, P. Carmines, E. Inscho, and S. Oparil
This article pays tribute to the tremendous achievements of Dr. László Rosivall in renal (patho)physiology research and nephrology education in Hungary on the occasion of his 60th birthday. For the past several decades Dr. Rosivall has been a charismatic leader of academic institutions, national and international societies, foundations in physiology, nephrology and hypertension, but the most important of his many contributions, is his role as a scientist. He earned his MD with Summa cum Laude at Semmelweis University (1973) and was invited immediately after that to join the laboratory of Hársing. He studied the distribution of intra-renal blood flow employing then state-of-the-art methods as well as developed his own technique at Semmelweis University and at the University of Bergen with Knut Aukland. This led to his PhD thesis and degree in 1980. An important determinant of his early basic scientific training and development was his postdoctoral research fellowship and later many visiting professorships in the Nephrology Research and Training Center (NRTC) at the University of Alabama at Birmingham, Birmingham, AL, USA between 1981 and 1983. Actually, this research fellowship not only impacted his own future career, but it also cleared the path for many other young Hungarian scientists who later trained with Dr. Rosivall and then at UAB. The early 1980s were the years of significant scientific discoveries and the NRTC team at UAB made important contributions by their studies on renal and glomerular hemodynamics, the renin-angiotensin system (12, 19, 22) and by the development of classic experimental techniques like renal micropuncture, microperfusion, and the juxtamedullary nephron preparation (3) that are still being used worldwide. When Dr. Rosivall joined UAB in the 1980s, the team at the NRTC included Drs. Navar, Bell, Inscho, Carmines, Casellas, and Oparil, among many others, who share their fond memories of working with Dr. Rosivall in this article.
Authors:B. Sági, A. Peti, O. Lakatos, T. Gyimesi, E. Sulyok, I. Wittmann, and Botond Csiky
In this observational study we addressed accelerated arteriosclerosis (AS) in patients with chronic renal failure (CRF) on hemodialysis (HD) by measuring vascular stiffness (VS) parameters and attempted to relate them to pro-inflammatory and protective factors.
96 consecutive patients receiving regular HD were included. 20 adult patients without major renal, cardiovascular or metabolic morbidities served as controls.
AS parameters (carotid-femoral pulse wave velocity – PWV, aortic augmentation index – Aix) were measured by using applanation tonometry (SphygmoCor, AtCor Medical, Sidney). In addition to routine laboratory tests 25(OH) vitamin D3 (vitamin D3) and high-sensitivity C-reactive protein (hsCRP) were quantified by immunometric assay; whereas fetuin-A, α-Klotho, tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) were determined by ELISA.
Pro-inflammatory biomarkers (hsCRP, TNF-α and TGF-β1) were markedly elevated (P < 0.01), while anti-inflammatory factors (fetuin-A: P < 0.05, α-Klotho: P < 0.01, vitamin D3: P < 0.01) significantly depressed in HD patients when compared to controls. PWV was significantly affected only by total cholesterol, fetuin-A and dialysis time. Multiple linear regression analyses revealed that several clinical and laboratory parameters were associated with pro- and anti-inflammatory biomarkers rather than VS. The impact of baseline clinical and biochemical variables on outcome measures were also analyzed after three-year follow-up, and it was demonstrated that low levels of vitamin D, α-Klotho protein and fetuin-A were related to adverse cardiovascular outcomes, whereas all-cause mortality was associated with elevated hsCRP and depressed vitamin D.
Our results provide additional information on the pathomechanism of accelerated AS in patients with CRF, and documented direct influence of pro- and anti-inflammatory biomarkers on major outcome measures.
Authors:P. Török, E. Tóth, K. Tóth, O. Valkó, B. Deák, B. Kelbert, P. Bálint, Sz. Radócz, A. Kelemen, J. Sonkoly, T. Miglécz, G. Matus, A. Takács, V. A. Molnár, K. Süveges, L. Papp, L. Papp Jr., Z. Tóth, B. Baktay, G. Málnási Csizmadia, I. Oláh, E. Peti, J. Schellenberger, O. Szalkovszki, R. Kiss, and B. TÓthmérész
For understanding local and regional seed dispersal and plant establishment processes and for considering the ecotypes and other forms of specific variability, hard data of locally or regionally measured traits are necessary. We provided newly measured seed weight data of 193 taxa, out of which 24 taxa had not been represented in the SID, LEDA or BiolFlor databases. Our new measurements and formerly published data of locally collected seed weight records together covers over 70% of the Pannonian flora. However, there is still a considerable lack in seed weight data of taxonomically problematic genera, even though they are represented in the Pannonian flora with a relatively high number of species and/or subspecies (e.g. Sorbus, Rosa, Rubus, Crataegus and Hieracium). Our regional database contains very sporadic data on aquatic plants (including also numerous invasive species reported from Hungary and neighbouring countries) and some rare weeds distributed in the southwestern part of the country. These facts indicate the necessity of further seed collection and measurements.
Authors:K. Török, K. Szilágyi, K. Halász, V. Zsigmond, G. Kósa, T. Rédei, E. Peti, J. Schellenberger, Z. Tóth, and K. Szitár
Seed bank collections have multiple benefits: store genetic material for conservation and research, and their data can also provide valuable scientific information. The Pannon Seed Bank was established during an EU LIFE+ project between 2010 and 2014 with the target to collect and store seeds of approx. 50% of the wild native vascular flora of the Pannonian Biogeographic Region, seed accessions of at least 800 storable species. This task was fully achieved by the end of the project, as altogether 1,853 seed accessions of 910 species are stored. The aim of the present paper is to provide access to the collection data and metadata of the Pannon Seed Bank as it was completed by the end of the project. The collection campaign involved about 40 experts and covered the whole country. Collection and storing applied standard methodology, based on the ENSCONET project. The collection data published in this paper can be used manifold. Geographical data on species occurrences are major input for nature conservation and research. Seed collection date is valuable for ecological studies of phytophagous insects, frugivorous birds and mammals, etc. The database can be partner to international databases (like GBIF) or research infrastructures (e.g. LifeWatch). Hopefully, this data paper will contribute to further motivate the development of native seed collections and their use for conservation and research in Hungary.