Authors:E. Sabbioni, R. Pietra, F. Mousty, F. Colombo, G. Rizzato and G. Scansetti
The possibility to use the bronchoalveolar lavage (BAL) in combination with analytical methods for trace metal analysis such as neutron activation analysis (NAA), inductively coupled plasma (ICP) and electrothermal atomic absorption spectroscopy (ETASS) for the determination of trace elements in the lung of living subjects has been investigated. In particular more than 30 elements have been determined: (1) in physiological solutions used for bronchopulmonary lavage (blank values) (2) in BALs of volunteer patients (unexposed subjects) (3) in BALs of occupational workers affected by pulmonary fibrosis as diagnosed by clinical methods (exposed subjects). Although the number of cases with metal exposure studied by NAA-BAL method is too limited to draw definitive conclusions the results suggest that the procedure can provide interesting qualitative information on metals which would be actually retained in the lung tissue. However, although the method may become of importance when integrated with clinical examinations further investigations are necessary to establish qualitative relations between trace metal levels determined in the BAL and the total elemental content of the lung tissue.
Authors:R. Pietra, E. Sabbioni, L. Ubertalli, E. Orvini, G. Vocaturo, F. Colombo and M. Zanoni
Neutron activation analysis (NAA) has been used for thedetermination of 26–31 elements in lung, urine, blood and nails of a photoengraver professionally exposed to cored arc light carbon fumes doped with cerium as well as a control group. The results show a clearly abnormal presence of rare earths in the lung of the worker. An evaluation was made of possible contamination during the sampling.
Authors:G. Guzzi, A. Colombo, F. Girardi, R. Pietra, G. Rossi and N. Toussaint
Three different analytical techniques: INAA, X-ray fluorescence and atomic absorption spectrometry were used at the JRC Ispra
to test the total homogeneity of four candidate botanic reference materials supplied by NBS. Without adopting complex statistical
formalities a “degree of inhomogeneity” was estimated in each sample for the elements considered in the test. The operating
procedures and the results obtained are presented and discussed.