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Evaluation of the involvement of nitric oxide and substance P in reducing baroreflex gain in the genetically hypertensive (GH) rat

Acta Physiologica Hungarica
Volume/Issue:
Volume 89: Issue 4
DOI:
https://doi.org/10.1556/aphysiol.89.2002.4.5
Authors:
Felicity Brady
,
Y. S. Bakhle
, and
C. Bell

The attenuation of baroreflex gain associated with hereditary hypertension couldinvolve abnormal signalling by nitric oxide or substance P. Baroreflex gain was measured in age-matched male genetically hypertensive (GH) and normotensive (N) anaesthetised rats from heart rate changes in response to i.v. phenylephrine or sodium nitroprusside. In subgroups of these animals, nitric oxide synthesis was inhibited using NG-nitro-L-arginine methyl ester (L-NAME, 30 mg.

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