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  • Author or Editor: G Hartmann x
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The purpose of this work was to study the role of 5-HT1A receptors on the level of anxiety in adult intact and ovariectomized (OVX) female rats. The influence of chronic administration of 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-HT1A receptor antagonist NAN-190 (0.1 mg/kg, i.p.) given for 14 days alone or in combination with 17µ-estradiol (0.5 µg i.m./rat/day) was studied on behavior in the elevated plus maze. In intact females administration of NAN-190 resulted in significant increase in the number of enterings and the time spent on the open arms in every phase of the estrous cycle, however, 8-OH-DPAT failed to modify these parameters. In OVX females 8-OH-DPAT alone or in combination with 17µ-estradiol significantly increased the number of enterings and time spent on the open arms. On the contrary, NAN-190 alone or in combination with 17µ-estradiol in OVX females failed to evoke behavioral changes in the elevated plus maze. Thus, the 5-HT1A receptor antagonist NAN-190 induced anxiolytic effect in intact female rats, while 5-HT1A receptor agonist 8-OH-DPAT produced an anxiolytic profile on OVX rats. Results of this work specify the involvement of 5-HT1A receptors in behavioral mechanisms of anxiety in OVX female rats.

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The influence of chronic administration of 5??1? receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-??1? receptor antagonist NAN-190 (0.1 mg/kg, i.p.) injected for 14 days alone or in combination with 17õ-estradiol (0.5 õg i.m./rat/day) was studied on passive avoidance performance (PAR) and on behavior in the open field test in adult intact and ovariectomized (OVX) female rats. Administration of 5-??1? receptor antagonist NAN-190 alone significantly improved PAR (p<0.05) in intact females with proestrus and estrus and in OVX females. Administration of 5-??1? receptor agonist 8-OH-DPAT alone or in combination with 17Ã-estradiol significantly (p<0.05) improved PAR in OVX rats and failed to normalize PAR in intact rats with proestrus and estrus. Results of the work specify the involvement of 5-??1? receptors in the mechanisms of passive avoidance learning in OVX female rats.

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Detailed studies of the gas release profiles of minerals and rocks reveal differences in the degassing rates and degassing temperatures and also in the compositions of the fluids evolved from the samples.

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Abstract  

A new method for the preparation of Tc metal from pertechnetate is described. Metallic technetium was prepared from TcO4 by initial reduction in dry argon atmosphere at 300 °C followed by a wet argon atmosphere in the presence of carbon between 700 and 910 °C. The higher temperature conditions in the presence of H2O and carbon form H2 and CO, which can drive the reduction of TcO2. This method was applied to the recovery of pertechnetate sorbed on anion-exchange resins resulting in the formation of Tc metal microspheres. The resulting Tc was characterized by XRD analysis and SEM.

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Journal of Radioanalytical and Nuclear Chemistry
Authors: F. Poineau, E. Rodriguez, P. Weck, A. Sattelberger, P. Forster, T. Hartmann, E. Mausolf, G. Silva, G. Jarvinen, A. Cheetham and Kenneth Czerwinski

Abstract  

The chemistry of technetium is being explored at the University of Nevada Las Vegas. Our goal is to investigate both the applied and fundamental aspects of technetium chemistry, with a special emphasis on synthesis, separations, and materials science. The synthetic chemistry focuses on metal–metal multiple bonding, oxides and halides. Synthesis and characterizations of (n-Bu4N)2Tc2X8, Tc2(O2CCH3)4X2 (X = Cl, Br), TcO2, Bi2Tc2O7, Bi3TcO8, TcBr3 and TcBr4 have been performed. The applied chemistry is related to the behavior of Tc in the UREX process. Separation of U/Tc has been conducted using anion exchange resin and metallic Tc waste form synthesized and characterized.

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