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Abstract  

Osteoarthritis, although classically conceived of as a degenerative consequence of aging, is a disease with an increasingly well-characterized molecular pathophysiology. Pathologic changes in cartilage composition and molecular organization, as well as elevated water content, alter the exquisite balance of biomechanical properties. Much of what is known about changes in the extracellular matrix in osteoarthritis comes from animal models. Previously, thermogravimetric methods have not been used for compositional thermoanalytical study of normal and degenerative human hyaline cartilage. For this reason the research group established a sufficient new thermogravimetric protocol, which proved water content elevation contributing to disease progression.

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On the oximine complexes of transitionmetals

Part CXIX. Thermal and spectral studies on Ni(Diox.H)2 type chelate compounds

Journal of Thermal Analysis and Calorimetry
Authors: Cs. Várhelyi Jr., G. Pokol, Á. Gömöry, A. Gănescu, P. Sohár, G. Liptay, and Cs. Várhelyi

Abstract  

Fourteen chelates of the type [Ni(II)(Diox.H)2], ((Diox.H)2: various α-dioximes) have been studied by means of FTIR, NMR, MS data and various thermoanalytical methods (TG, DTA, DTG, DSC). In some cases kinetic parameters of the thermal decomposition of the complexes were also calculated using Zsak’s ‘nomogram method’. The mechanism of the decomposition processes was characterised on the basis of mass spectra.

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Abstract  

The purpose of this investigation was to further elucidate calorimetric properties of cartilage samples from femoral head necrosis and osteoarthritis from live surgeries. The natural course of this disease is one of steady progression with eventual collapse of the femoral head, followed by secondary osteoarthritis in the hip joint. All samples showed a clear denaturation peak on the calorimetric curve. Cartilage obtained from necrotic femoral head required the lowest amount of energy for decomposition. The use differential scanning calorimetry as part of thermal analysis was a reliable method for differentiating.

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Abstract  

The purpose of this study was to further characterize the altered metabolism spondylolisthesis that promotes disease progression. Degenerative human cartilage (intervertebral disc, facet joint and vertebral end-plate) was obtained during 15 posterior lumbar spine interbody fusion procedures performed at the University of Szeged. The thermal properties of samples were determined by differential scanning calorimetry (Mettler-Toledo DSC 821e). Greatest change in the enthalpy was observed in the intervertebral disc samples: −1600.78 J g−1. Denaturation caused by heating in the normal human hyaline cartilage needed −1493.31 J g−1 energy. Characterization of the altered metabolism that promotes disease progression should lead to future treatment options.

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Abstract  

The glenohumeral joint is not a classical mass bearing joint, the treatment of primary osteoarthritis is conservative. In all other cases, when the arthritis is associated with unbalance of the soft tissues, the treatment solution of this pathology is arthroplasty. The purpose of this study was to examine the altered metabolism in human degenerated cartilage of the shoulder joint. With the rise of temperature an endothermic reaction was observed in all cases. The use differential scanning calorimetry as part of thermal analysis was a reliable method for differentiating normal hyaline cartilage from degenerated samples.

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Abstract  

During recent years, knowledge of rheumatoid arthritis has increased, and management of the disease has improved. A limited number of papers have been published before on the subject of thermal analysis of degenerative cartilage but rheumatoid arthritis (RA) has not been studied previously. A new protocol had to be established before the investigation. The purpose of this study was to further characterize the altered metabolism in human RA cartilage that promotes disease progression. Previously, these methods have not been used for this purpose. The use of thermal analysis could be an effective method for controlling the relationship between biomarkers and disease progression.

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