Authors:Petr Kastner, Jiří Klimeš, Gabriela Zimová, and Věra Klimešová
RPTLC retention characteristics have been examined for two series of potential antituberculotic drugs. Various effects were tested which can be manifested in the values of properties measured — i.e. the effect of the type and proportion of the organic component of the mobile phase, and the effect of the pH of the aqueous component of the mobile phase. Experimentally obtained measures of lipophilicity were correlated with each other and with values calculated by a computational method. In this study some substituents, in particular nitro groups or more complicated substitution of the aromatic ring, negatively affected the correlation of the measured values with those calculated.