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Interventional Medicine and Applied Science
Authors: Ludmila Davydova, Gennadii Tkach, Alexey Tymoshenko, Alexey Moskalenko, Vitalii Sikora, Ludmila Kyptenko, Mykola Lyndin, Dmytro Muravskyi, Olena Maksymova, and Olga Suchonos

Purpose

The purpose of this paper is to describe the research results of the morphological structure of white laboratory rats’ tongue at the macro-, micro-, and ultrastructural levels by scanning, light, and transmission electron microscopy.

Results

Our results show that the tongue of these rats has a number of unique morphological features that are different from the tongue of other rodents consequently to allow identifying their species-specific features.

Conclusions

Our findings have shown the features of the tongue structure of white laboratory rats at micro-, macro-, and ultrascopic levels. The data analysis revealed that mucous membrane of the tongue contains a large number of papillae, such as fungiform, filiform, foliate, vallate, and multifilamentary papillae. Each has a different shape, size, and location. The tongue’s morphological feature consists of three types of filiform papillae, well-developed foliate and multifilamentary papillae, as well as one large and similar smaller circumvallate papillae. The muscle of the tongue contains a large number of mitochondria of different shapes and sizes. However, we have received data for a complete picture of structure of this organ that will be useful in further experimental and morphological studies of the white laboratory rats.

Open access
Interventional Medicine and Applied Science
Authors: Alexey Tymoshenko, Gennadii Tkach, Vitalii Sikora, Valentina Bumeister, Ihor Shpetnyi, Mykola Lyndin, Olena Maksymova, and Anna Maslenko

Purpose

The article is devoted to study the structural changes in the skeletal muscles caused by heavy metal salts.

Materials and methods

The study was conducted on 72 mature male rats. The experimental groups were given to drink water with combinations of heavy metal salts for one, two and three months. This type of water is typical for the water basins in the northern districts of the Sumy region. The study of morphological changes in the striated muscles was concluded using light and scanning electron microscopy.

Results

The data analysis revealed that a prolonged duration of negative factor could intensify sclerotic and edematous processes. The structure of muscle fibers was destroyed, nuclei were deformed and placed irregularly, and many petechial hemorrhages occurred. Besides, cross-striation was irregular, I and A bands were deformed and destroyed, H band was hardly visualized. The inner mitochondrial membrane and cristae become deformed. The symplastic nuclei were placed irregularly within sarcoplasm. Besides, they were swollen. Against swollen and enlarged symplastic nuclei, pyknotic nuclei were also found. The structures of sarcoplasmic reticulum were mainly dilated with deformed and ruptured areas.

Conclusion

Our study approves that high concentrations of heavy metal salts have a destructive influence on the skeletal striated muscles.

Open access