43K is used in diagnostic nuclear medicine for body electrolyte and cardiovascular investigations. This nuclide is produced
at LAMPF by the spallation of V targets with medium-energy protons, and a chemical procedure has been developed for the isolation
of radiopotassium from the bulk target material and various spallogenic impurities.43K is thus recovered with a 91% chemical yield and is sufficiently decontaminated for radiologic applications.
Authors:P. Grant, G. Montero, A. Newman, and H. O'Brien
The first use of the172Hf–172Lu generator system in industry is reported. Millicurie quantities of172Lu have been utilized for radiotracer studies of oil pipeline flow rates, refinery column residence times, and the performance of a coal liquefaction pilot plant.
Authors:P. Grant, R. Daniels, W. Daniels, G. Bentley, and H. O’Brien
A solvent extraction system has been developed for the separation of172Lu from its long-lived172Hf parent. The parent-daughter pair in equilibrium is maintained in a solution of HDEHP, and the heavy lanthanide daughter
is extracted into 9M HCl. The separation factor for this generator is approximately 104. The rare-earth activity so obtained is proposed for compound labelling research and animal biodistribution studies in nuclear
Authors:P. Horlock, J. Clark, I. Goodier, J. Barnes, G. Bentley, P. Grant, and H. O’Brien
82Sr has now been produced by the spallation of Molybdenum by protons of up to 800 MeV. The radiochemical recovery of strontium
is described together with a description of the analytical techniques used to estimate recovered yields of the various radionuclides
generated. A radionuclide generator is described for the rapid recovery of82Rb, the 1.25 min half-life decay product of82Sr. An outline is given of the quality control procedure adopted to ensure that the82Rb is suitable for clinical use.
Authors:D. Miller, M. Grant, B. Erdal, R. Whipple, and H. O'Brien
Proton spallation is a relatively recent method for significant radioisotope production. A detailed discussion of the activation equation for charged-particle reactions is given, and measured values of spallation cross sections for reactions of 800-MeV protons with three target materials are reported.
Reducing the risk of developing chronic disease, such as obesity and type 2 diabetes, is an important component of successful aging. Offspring born to mothers who exercise during pregnancy have improved body composition and metabolic profiles. However, mechanisms to explain this phenomenon are lacking.
This study examined whether maternal step counts were correlated with neonatal gene expression markers related to glucose metabolism and adipogenesis.
Physical activity levels were assessed in women with male neonates via Fitbit Flex® during the second and third trimester of pregnancy. The dartos and epidermal/dermal layers of the foreskin were collected following circumcision in full-term, singleton, neonates (n = 12 dartos and n = 14 dermal). Tissue was homogenized, RNA isolated, and a NanoString code set was run to quantify a panel of genes related to glucose metabolism and adipogenesis.
Twelve genes were correlated to steps per day with a P-value of <0.05. After adjusting for multiple comparisons, six genes remained significantly correlated to steps per day (False Discovery Rate-corrected P-value < 0.10). Notably, glucose transporter 1, adiponectin receptor 1, and CCAAT/enhancer-binding protein alpha and beta were positively correlated with steps per day, while peroxisome proliferator-activated receptor alpha and peroxisome proliferator-activated receptor gamma coactivator 1- alpha were negatively correlated with steps per day.
Maternal physical activity is associated with offspring gene expression markers of adipogenesis, insulin sensitivity and glucose uptake. Future studies should aim to mechanistically examine whether these markers are driving increased adiposity in offspring born to sedentary mothers.