The present study was undertaken to determine the structure of67Ga-binding acid mucopolysaccharide in tumor tissues. It was determined from measuring neutral saccharide in the structure that the principal67Ga-binding acid mucopolysaccharide in the tumor was keratan sulfate and/or keratan polysulfate. On the other hand, it was clarified from the results of mucopolysaccharase treatment that the main67Ga-binding acid mucopolysaccharide in tumor was not keratan sulfate, heparan sulfate, heparin, nor chondroitin sulfate A, B, or C. Based on the present results, it was deduced that the main67Ga-binding acid mucopolysaccharide in tumor is keratan polysulfate and that this acid mucopolysaccharide plays the most important role in tumor accumuation of67Ga.
Trivalent hard acids (Ga3+, In3+, Yb3+, Tm3+), which have complete d-shells, were bound to the acid mucopolysaccharide with a molecular mass of about 10,000 Daltons in soft tissue. Tri-, tetra-, and pentavalent hard acids and some borderline acids which have incomplete d-shells were bound to the acid mucopolysaccharides, whose molecular masses exceed 40,000 Daltons in soft tissues. Based on these results and the facts reported previously a very interesting relationship was recognized between the location of elements in the Thomsen-Bohr periodic table and the substances to which they bind.
For improvement of radionuclidic purity of123I a method was elaborated to obtain highly enriched [123Te] tellurium. Using this new TeO2 target the optimum irradiation conditions have been investigated for the production of123I via123Te (p,n)123I and the radionuclide impurity levels were also determined.
An improved method has been developed to obtain highly enriched [123Te] tellurium for the production of medically important123I. Excitation function of the123Te(p,n)123I reaction, production yields and radionuclidic impurity levels were determined as a function of bombarding energy and target thickness.
We analyzed the heterogeneity of
hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria. On the basis of the expression or the lack of expression of blood cell antigens the following hemocyte populations have been defined: crystal cells, plasmatocytes, lamellocytes and precursor cells. The expression of the antigens and thus the different cell types are developmentally regulated. The hemocytes are arranged in four main compartments: the circulating blood cells, the sessile tissue, the lymph glands and the posterior hematopoietic tissue. Each hemocyte compartment has a specific and characteristic composition of the various cell types. The described markers represent the first successful attempt to define hemocyte lineages by immunological markers in
and help to define morphologically, functionally, spatially and developmentally distinct subsets of hemocytes.