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Journal of Thermal Analysis and Calorimetry
Authors: Ana Santos, I. Basílio, F. de Souza, A. Medeiros, Márcia Pinto, D. de Santana, and R. Macêdo

Abstract  

Thermal analysis is an essential analytical tool in development of new formulations as well as to study the interaction between drugs and excipients. This work aims to investigate the possible interactions between metformin and excipients as microcrystalline cellulose (Microcel MC101®), starch sodium glycolate (Explosol®), sodium croscarmellose (Explosel®), PVP K30, magnesium stearate, starch and lactose, usually employed in pharmaceutical products. TG, DSC and DTA techniques were used for the thermal characterization to track if the thermal properties of the drug substance were modified in the mixture. Disregard of the starch and lactose systems, no changes in thermal behavior of mixtures were found. Thermogravimetric studies (TG) of metformin and its binary mixtures showed different thermal behavior.

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Journal of Thermal Analysis and Calorimetry
Authors: Nadábia de Souza, F. de Souza, I. Basílio, Ana Medeiros, E. Oliveira, Ana Santos, R. Macwdo, and R. Macędo
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