Authors:I. Labádi, R. Tudose, I. Fejér, Z. Jóri, and O. Costisor
Parent and mixed ligand complexes of cobalt and copper with antipyrine derivatives of 1,2-ethanediamine or piperazine and
with 2-aminobenzothiazole (TAB) were synthesized and their thermal behaviour was investigated. The complexes contain N,N′-bis(4-antipyrylmethyl)-piperazine
(BAMP) or N,N′-tetra(4-antipyrylmethyl)-1,2-diaminoethane (TAMEN) or/and TAB as ligand, and Cl−, ClO4− or SCN−. The complexes decompose with the evolution of heat. The decomposition route depends on the presence of ClO4−. If the ClO4− is not coordinated, it oxidizes the TAB and BAMP or TAMEN and the decomposition is explosive.
Authors:György Fejer, M. Freudenberg, U. F. Greber, and I. Gyory
Adenoviruses are important infectious agents and also emerging vectors in different biomedical applications. These viruses elicit a strong innate and adaptive immune response, which influences both the course of disease and the success of the applied vectors. Several Toll-like Receptor (TLR)-dependent and -independent mechanisms contribute to these responses. Understanding of the involved viral and cellular factors is crucial for the treatment of various adenovirus diseases and the optimal design of adenovirus vector applications. Here we summarize our current understanding of the complex nature of adenovirus-induced innate immune mechanisms.