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  • Author or Editor: Ilona Szentmihályi x
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Plant drug mixtures are widely used in the adjuvant therapy of type 2 diabetes mellitus for the prevention of complications. The drug mixtures generally contribute to the efficiency of the therapy and may also reduce undesirable side effects. Two herbal extracts (lyophilized aqueous extracts of plant drug mixtures 1: Myrtilli folium, Phaseoli fructus sine seminibus and 2: Myrtilli folium, Phaseoli fructus sine seminibus, Salviae folium ) were investigated in in vitro rat models. The content of bioactive constituents (polyphenol, flavonoid and vitamin C) in plant drug mixtures and lyophilized samples was evaluated. The antioxidant activity of lyophilized extracts was determined by measuring the ferric reducing ability of the plant, Fe 2+ induced lipid peroxidation (LPO) in rat brain homogenates and NADPH (β-nicotinamide adenine dinucleotide phosphate reduced form) induced LPO in cerebral microsomes. The antioxidant activity of lyophilized extracts was compared to that of quercetin and rutin. Both teas of lyophilized extracts had significant reducing ability (2694 and 2771 μmol/l) and inhibited LPO (IC 50 28.0 and 20.6 μl in NADPH induced LPO, 17.3 and 8.7 μl in Fe 2+ induced LPO). The high concentration of polyphenol/flavonoid (12.38–13.00 and 1.45–5.22 g/100 g, respectively) and vitamin C (0.099–0.165 g/100 g) in the herbal extracts is related to their significant antioxidant properties. The tea mixtures have significant nutritional value, since the consumption of 2 or 3 cups of tea a day covers 50% of the daily requirement of vitamin C and it is also relevant polyphenol source. The high polyphenol/flavonoid content may restore the redox imbalance and contribute to the prevention of diabetic complications.

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Acta Biologica Hungarica
Authors: Klára Szentmihályi, Ilona Szöllősi Varga, Anita Gergely, Mária Rábai, and Mária Then

Tinctures are almost the oldest medicines and their use is substantial in the medication nowadays as well. The antioxidant values by ferric reducing/antioxidant power (FRAP) method and element content by inductively coupled plasma optical emission spectrometry (ICP-OES) were investigated in some tinctures official in the VII. and VIII. Pharmacopoeia Hungarica. The highest FRAP values were found for volatile oil containing Tinctura Aurantii amari epicarpii et mesocarpii, Tinctura Amara and Tinctura Valerianae (764.54±19.90; 757.37±14.46; 826.40±5.89 µmol l−1, respectively). The correlations between the FRAP values and dilution with different alcohol content in Tinctura Chinae, Tinctura Ipecacuanhae normata and Tinctura Strychni were also investigated. Remarkable differences were found between the element concentrations in the different tinctures. The element contents in tinctures are not so high in absolute values nevertheless the presence of essential selenium, zinc, manganese and copper is important since they have key role in the antioxidant system. The common feature of the tinctures seems to be the lithium content. The Ca to Mg concentration ratio was found to be shifted towards magnesium in some of the tinctures that can show a higher Mg absorption which could affect against the proinflammatoric processes in the cases of gastrointestinal diseases.

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Magyar Sebészet
Authors: Ilona Szentmihályi, János Imre Barabás, Ágnes Bali, Gábor Kapus, Csilla Tamás, Balázs Sax, Endre Németh, Miklós Pólos, László Daróczi, Andrea Kőszegi, Chun Cao, Kálmán Benke, Péter Barnabás Kovács, Levente Fazekas, Zoltán Szabolcs, Béla Merkely, and István Hartyánszky

Absztrakt

A szívtranszplantáció kiemelt projekt lett a Semmelweis Egyetemen belül. Ennek megfelelően a szívátültetés és a mechanikus keringéstámogatás finanszírozása is rendkívüli jelentőséget kapott. A szerzők a transzplantációs és műszíves betegek költségeinek összehasonlításáról végzett költséghatékonysági számítási modell felépítéséről számolnak be. A modell megalkotásánál direkt allokációs költségszámítást, döntésifa-modellt, inkrementális költséghatékonysági rátát és költséghatékonysági térképmódszert használtak. Módszerükkel össze tudják hasonlítani a műszívbeültetésen átesett és a szívtranszplantációs betegcsoportok kezdeti, perioperatív és utókezelési költségeit. Modelljük alkalmas lehet hosszú távú utánkövetés és kellő elemszámú beteg bevonásával költséghatékonysági elemzések elkészítésére, gazdasági döntéstámogató következtetések meghozatalára.

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