Authors:Antonilêni Medeiros, Ana Santos, F. de Souza, I. Júnior, J. Valdilânio, J. Procópio, D. de Santana, and R. Macêdo
Compatibility studies between active drugs and excipients are substantial in the pharmaceutical technology. The objective
of the present work was to develop pre-formulated mixtures of metronidazole (MT) obtained by spray drying (SPDR) and their
thermoanalytical characterization. Dynamic and isothermal TG, conventional DSC and DSC coupled to a photovisual system were
used. DSC experiments with both techniques confirmed the homogeneity of the conventional and pre-formulated mixtures. The
TG data made possible the comparison the thermal stability of the different mixtures. Similar thermal stabilities were found
of the conventional and pre-formulated mixtures, with slower particles sizes of MT.