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  • Author or Editor: Jiří Klimeš x
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Reversed-phase (RP) TLC retention behavior has been examined for two series of potential antituberculotic drugs. Effects of the type and proportion of the organic component of the mobile phase were tested, because these can affect retention. Experimentally measured lipophilicity values and values calculated by means of a computational method were compared to determine the extent of any correlation. It was found that substitution of the aromatic ring, in particular with chlorofluoro or more complicated substituents, negatively affected the correlation between measured and calculated values.

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RP-TLC retention behavior has been studied for a series of potential antituberculotic drugs from a group of substituted anilides of pyrazine-2-carboxylic acid. Lipophilicity was determined by use of reversed-phase thin-layer chromatography with methanol-water mobile phases. R MW values were obtained by extrapolation of R M (determined by RP-TLC) to methanol-free conditions. These experimental lipophilicity values were correlated with lipophilicity (log P ) calculated by use of three software products. Good correlation was obtained between R MW and log P . The results of this study could be used in further experiments focused on investigation of the biological activity of these newly prepared compounds and other potential antituberculotic drugs with closely similar chemical structures.

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RPTLC retention characteristics have been examined for two series of potential antituberculotic drugs. Various effects were tested which can be manifested in the values of properties measured — i.e. the effect of the type and proportion of the organic component of the mobile phase, and the effect of the pH of the aqueous component of the mobile phase. Experimentally obtained measures of lipophilicity were correlated with each other and with values calculated by a computational method. In this study some substituents, in particular nitro groups or more complicated substitution of the aromatic ring, negatively affected the correlation of the measured values with those calculated.

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RPTLC retention characteristics have been examined for a series of potential antituberculotic drugs derived from 2-benzylsulfanylbenzothiazole. The effects of the type and proportion of the organic component of the mobile phase were investigated. Experimentally obtained measures of lipophilicity were correlated with each other and with values calculated by a computational method. Some substituents, e.g. nitro and chlorofluoro groups, or more complicated substitution of the aromatic ring, negatively affected correlation of measured values with those calculated.

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