Authors:Ketan Pimparkar, Bernard Yen, John R. Goodell, Veronique I. Martin, Wen-Hsuan Lee, John A. Porco Jr., Aaron B. Beeler and Klavs F. Jensen
In an effort to utilize microfluidics to enable photochemistry, we have devised a method for fabrication of devices with UV-transmissive glass. The photochemical device is successfully incorporated into a system utilizing high-pressure capillary mercury lamps and cooling system. We have demonstrated the ability to carry out photochemical transformations with substantial rate acceleration. Furthermore, we highlight the ability to carry out analytical-scale reactions on a pulse flow automated system while modulating wavelength and residence time to identify optimal photochemical reaction conditions. The analytical conditions were also successfully converted to continuous-flow preparative scale.