Search Results

You are looking at 1 - 10 of 25 items for

  • Author or Editor: Kamal x
  • Refine by Access: All Content x
Clear All Modify Search

Abstract  

We give some conditions under which an R-endomorphism f fixing an essential ideal I of a right near-ring R must be the identity R-automorphism on RR. As a consequence of the results obtained we generalize the theorem of [1].

Restricted access

Abstract  

Mössbauer spectra of alkali tris(maleato) ferrates(III), i.e., M3[Fe(C2H2C2O4)3nH2O [M=Li, Na, K, Cs] at 300 K display a doublet. The Mössbauer parameters indicate these complexes to be high spin with octahedral symmetry. The isomer shift shows a decreasing trend with the increase in electronegativity/polarizing power of the substituent cation (Li+, Na+, K+, Cs+). A linear correlation between isomer shift values and the (Fe−O) stretching frequencies has also been observed.

Restricted access

Autoimmune hepatitis is defined as chronic liver disease of unknown aetiology with aberrant autoreactivity and genetic predisposition. It is characterized by female predominance, circulating auto-antibodies, hypergammaglobulinaemia and association with HLA DR3 and HLA DR4 [1]. Differential diagnosis includes chronic viral hepatitis, drug induced hepatitis and alcohol. We present two patients with autoimmune hepatitis representing the two extremes of hepatic involvement in this condition. The first patient is a young lady who was diagnosed with autoimmune chronic hepatitis. The second patient, on the other hand, is an elderly gentleman who presented to us with autoimmune hepatitis-related decompensated cirrhosis of liver.

Restricted access

Introduction: The aim of this study is to compare Knodell and HAI scores in patients with wild type and precore/core promoter mutant CHB to see if there is any difference in severity of liver injury between these two types of HBV. Methods: We did percutaneous liver biopsies of 155 CHB patients. 102 (65.8%) of them were infected wild type HBV and the rest 53 (34.2%) were infected with precore/core promoter mutant CHB. Results: 11/53 (20.8%) patients with precore/core promoter mutant CHB had moderate to severe CH (HAI score 8–18). In contrast, moderate to severe CH was seen in 19/102 (18.6%) patients with wild type CHB. Fibrosis score was >2 in 15/53 (28.3%) precore/core promoter mutant CHB as opposed to 20/102 (19.6%) patients with wild type CHB. Conclusion: The study shows that precore/core promoter mutant HBV produces more severe histologic liver disease compared to wild type HBV.

Restricted access

Metoprolol tartrate is rapidly absorbed from both gastric and intestinal regions, after oral administration. To retard the release rate of the metoprolol tartrate, microspheres were prepared with varying concentrations of a mixture containing ethylcellulose and polyethylene glycol-6000. The prepared microspheres were evaluated for various physicochemical characteristics and in vitro drug release. The percent yield of microspheres was in the range of 75.2–87.3%. The particle size of microspheres was found to be in the range of 73.2–85.5 μm. Fourier transform-infrared spectral analysis and differential scanning calorimetry concluded the absence of any interaction between the drug and the carriers. The release time profile of metoprolol tartrate from microspheres in 0.1 N hydrochloric acid solution was to the extent of 33.4–60.2%. The complete release of metoprolol tartrate occurred from MPT-3 and MPT-4 in phosphate buffer solution (pH 7.4) within 8 and 7 h, respectively, whereas the incomplete release (72.3%) occurred from MPT-1. Nearly, the complete release (98.5%) of metoprolol occurred from MPT-2 in 10 h. Formulation MPT-2 would be a preferred formulation. The release of metoprolol involves diffusion rate limited (R 2 = 0.9865) as a mechanism from drug release. The prepared microspheres of metoprolol tartrate eliminate the need for multiple dosing and provide patient compliance.

Open access
Journal of Radioanalytical and Nuclear Chemistry
Authors: Alireza Khorami-Moghadam, Amir Jalilian, Kamal Yavari, Bahram Bolouri, Ali Bahrami-Samani, and Mohammad Ghannadi-Maragheh

Abstract  

Antiangiogenic monoclonal antibodies in combination with therapeutic radionuclides are potential targeted therapy agents in cancer. In this study, bevacizumab was successively labeled with [166Ho]HoCl3 after conjugation with DOTA-NHS-ester with a radiochemical purity of higher than 95% (RTLC). The conjugates were purified by molecular filtration, the average number of DOTA conjugated per mAb was calculated and total concentration was determined by spectrophotometric method and the average chelate to antibody ratio (c/a) for the conjugate used in this study was 5.8:1 and protein integrity experiments (SDS-PAGE). The biodistribution studies in wild-type rats demonstrate a similar pattern to the other radiolabeled anti-vascular endothelial growth factor A (VEGF-A) immunoconjugates. 166Ho-DOTA-bevacizumab is a potential compound for therapy/imaging of VEGF-A expression in oncology.

Restricted access
Clinical and Experimental Medical Journal
Authors: Mamun-Al-Mahtab, Kabir Uddin, Salimur Rahman, Mobin Khan, Kamal, Moniruzzaman Bhuiyan, and Gulzar Hussain

Abstract

Primary biliary cirrhosis (PBC) is a rare autoimmune liver disease, not infrequent in the West, but hardly reported from the East. We report a case of PBC for the first time from Bangladesh. The patient was an elderly woman presenting with vague complaints. The diagnosis was confirmed by antibody testing and histopathology, whereas other possible causes of cirrhosis were also excluded.

Restricted access

The quarry blasting is one of the artificial explosions that produces stresses in the ground and may have a great effect on the near foundations. The estimation of the stress level either in the weathering layer or the bedrock is necessary for the safety of the existing buildings near the quarries. Cement Companies has been in operation since 1956 close to Helwan City, Egypt. Since then, new buildings and new communities were established in the area such as the City of 15th of May. For the safety of these buildings, detailed and continuous monitoring of the peak particle velocity of the quarry blasting operations was carried out since January 1997 till September 2000. The maximum values of the stress level for the weathering layer has been found smaller than that for the bedrock for both of the P- and S-waves. The damage observed in the buildings close to the quarry blasting operations, indicates that these stress levels are high.

Restricted access