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Canine influenza virus (CIV) is an enveloped virus belonging to the genus Influenza virus A within the family Orthomyxoviridae. Prior to 2004, only sporadic outbreaks of canine influenza had been observed in dog populations around the world. However, in 2004 an H3N8 influenza virus of equine origin caused severe respiratory disease in racing greyhounds in Florida; subsequently, cases of dogs affected with various subtypes of CIV have been reported in many countries. Here, we performed a structured review of CIV, including its emergence, evolution and epizootiology. Although CIV causes a disease of low mortality, the potential public health threat it poses due to close contact between dogs and humans highlights the necessity of promoting surveillance for this virus.

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Abstract

Journal impact factor (JIF) has been used for journal evaluation over a long time, but also accompanied by the continuing controversy. In this study, a new indicator, the Journal's Integrated Impact Index (JIII) has been proposed for journal evaluation. In the JIII, one journal's average citations per paper, total citations, and all journals’ average level of average citations per paper and total citations have been used to characterize the integrated impact of journals. Some contrastive analyses were carried out between JIII and JIF. The results show some interesting properties of the new indicator, and also reveal some relevant relationships among JIII, JIF, and other bibliometric indicators.

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Abstract

Narciclasine is a 7-hydroxy derivative of lycorisidine. It was the first alkaloid isolated from the stem of narcissus (Amaryllidaceae) in 1967. Six mice were given narciclasine (5 mg/kg) by intravenous administration. A UPLC-MS/MS method was developed to determine narciclasine in mouse blood. Tectorigenin (internal standard, IS) and narciclasine were gradient eluted by mobile phase of methanol and 0.1% formic acid in a BEH C18 column. The multiple reaction monitoring (MRM) of m/z 308.1→248.1 for narciclasine and m/z 301.1→286.0 for IS with an electrospray ionization (ESI) source was used for quantitative determination. The calibration curve ranged from 1 to 6,000 ng/mL. The accuracy was from 92.5 to 107.3%, and the matrix effect was between 103.6 and 107.4%. The developed UPLC-MS/MS method was successfully applicated to a pharmacokinetic study of narciclasine in mice after intravenous administration (5 mg/kg).

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Abstract  

In boron neutron capture therapy (BNCT), the proportion of the fast neutron in the tumor (PFN) must be no more than 3%. If a D–T neutron generator is used as a thermal neutron source in BNCT, the moderator must be optimized to decrease the PFN. Based on the analysis of the theory, water, heavy water, polythene, graphite, lead, and tungsten were used to moderate the fast neutrons. If the three-layer material is composed of a 4 cm thickness layer of tungsten, a 13 cm thickness layer of lead, and a 23 cm thickness layer of heavy water, its thermalization efficiency (TE) is highest, which is increased by 191.5% than the maximum TE moderated by single-layer materials and by 19.3% than the maximum TE moderated by double-layer materials.

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Acta Chromatographica
Authors:
Shuanghu Wang
,
Zixia Lin
,
Ke Su
,
Jing Zhang
,
Lijing Zhang
,
Zhimou Gao
,
Zhiyi Wang
,
Jianshe Ma
, and
Xianqin Wang

The rats were randomly divided into paraquat group, curcumin treatment group, and pirfenidone treatment group. The concentration of paraquat in rat plasma was determined by an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method over the range of 10–2000 ng mL−1. Chromatographic separation was achieved on a BEH HILIC (2.1 mm × 100 mm, 1.7 μm) column. The mobile phase was consisted of acetonitrile and 10 mm ammonium formate buffer (containing 0.1% formic acid) with gradient elution pumped at a flow rate of 0.4 mL min−1. Protein precipitation with acetonitrile was used as sample preparation. Compared with the paraquat group, there is statistical toxicokinetic difference for curcumin treatment group and pirfenidone treatment group, AUC(0 − t) decreased (P < 0.05), clearance (CL) increased (P < 0.05) for curcumin or pirfenidone treatment group, and C max decreased (P < 0.05) for curcumin treatment group. The results showed that treatment by curcumin and pirfenidone could relieve acute paraquat poisoning in rats.

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