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  • Author or Editor: L. Boháčik x
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Abstract  

The possibility of use of a powder-like polymeric hydrogel of 2-hydroxyethyl methacrylate with 33 wt.% methacrylic acid as potential pharmaceutical adjuvant in the form of a composite powdered material, with silicone rubber in the form of matrices for transdermal therapeutic system has been studied. The effect of solvents and the content of composite hydrogel in matrices on the rate of permeation of an antianginic drug, radioactive labeled glycerol trinitrate (GTN) was evaluated. The results show that hydrogel copolymers are prospective adjuvants for transdermal therapeutic systems.

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Abstract  

Permeation of metal Cs+ ions from water solutions across the intact, stripped and splitted skin of 5- or 9-day old rat was studiedin vitro using vertical diffusion cells. The results showed that the stratum corneum (horny layer) of this new animal skin model represents the principal pentration barrier. The relative importance of the percutaneous absorption of Cs+ ions through transepidermal and transfolicular routes has been assessed comparing the penetration across skin without hairs and skin just haired. The results have shown that the shunt diffusion along hair follicles can be of preponderant value.

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Abstract  

Three methods of atropine and scopolamine determination in transdermal permeation have been developed. Radiometric determination seems to be an excellent, quick and extremely sensitive method, which ought to be preferred when working with biological systems. The radioreceptor analysis is of group specificity. It can be used to advantage in monitoring atropine plasma concentrations exceeding 1.5 ng cm–3 and scopolamine concentrations above 50 pg cm–3. GC/MS provides adequate specificity and sensitivity for the determination of therapeutic levels of atropine and scopolamine in blood. The sensitivity of this method is approximately 1–2 ng cm–3.

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