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  • Author or Editor: L. Nagymajtényi x
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Rats were treated with a combination of insecticide agents in different timing schemes. In acute administration, 1/5 LD50 of the three insecticides: dimethoate, propoxur and cypermethrin, or their combination, was given once by gavage. In the developmental model, female rats received oral doses of 1/25 LD50 of the above insecticides in combination in three timing schemes including pregnancy and lactation. Responses in the somatosensory cortex and in the tail nerve, evoked by peripheral electric stimulation, were recorded in acute preparation under urethane anesthesia. It was tested whether the parameters of the cortical and peripheral evoked response are dependent on the frequency and whether this dependence is different in control and treated animals. The latency increase of the cortical responses with increasing stimulation frequency was significantly stronger in rats treated acutely with cypermethrin and the combination, and in rats receiving the combination during both intra- and extrauterine development. On the duration, the effects were less clear. Frequency dependent increase of the tail nerve action potential latency was significantly intensified by cypermethrin, and the amplitude decrease, by cypermethrin and dimethoate. Fatigue of this response during a stimulation series was also altered by the insecticides. Frequency dependence and fatigue possibly reflect the actual state of the nervous system and may have the potency to be developed to functional biomarkers.

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This study investigates the relationship between the characteristics of healthy nutrition and other lifestyle factors and state of health in youth. A total of 330 men of 10 to 25 years of age with light, moderate and high level of physical activity were involved in this cross-sectional study. A self-administered questionnaire was used as a method of data collection. The positive dietary factors were scored on the basis of a self-reported food frequency questionnaire about the past month consumption of foods. In the univariate analysis age, physical activity and smoking was proven to be in relationship with dietary habits, while body mass index or self-rated health not. The health behaviour of sportsmen showed different picture indicating that active sport is not unequivocally resulted in healthier dietary habits.

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Acta Alimentaria
Authors:
S. Balogh
,
F. Hajnal
,
B. Belec
,
M. Kómár
,
R. Papp
,
L. Nagymajtényi
, and
E. Paulik

Several risk factors of diet-related diseases are present in the nutrition of the Hungarian population. The aim of the study was to investigate the health status and the association of the daily consumption of fruits and vegetables as indicators of healthy diet with sociodemographic factors, health behaviours in the south-eastern part of Hungary. In 2002, a cross-sectional study based on interviewer-administered questionnaires was conducted in the south-eastern part of Hungary. The sample comprised of 3419 people, aged between 15 and 75, with about 40 persons from each practice. The results demonstrated that fruit and vegetable consumption of the studied population were determined by certain demographical, economical and lifestyle factors, and were also associated with self-assessed health and health status.  Altering the habits of nutrition is an integral part of health intervention programs. Success rate may, however, be largely reduced by the social and economic background of the habits in question.

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Acta Biologica Hungarica
Authors:
L. Institóris
,
Dóra Kovács
,
I. Kecskeméti-Kovács
,
Anita Lukács
,
Andrea Szabó
,
Zsuzsanna Lengyel
,
A. Papp
,
L. Nagymajtényi
, and
I. Dési

Detectable interactions between NOEL (No Observed Effect Level) doses of Pb, Hg and Cd in general toxicological, hematological, and immune function parameters were investigated. The metals (Pb-acetate, 20 mg/kg; HgCl2, 0.40 mg/kg; CdCl2, 1.61 mg/kg) were combined. First, the rats received the combination Pb+Hg+Cd for 4 weeks per os. Significant difference vs. control was found only in the weight of lung and popliteal lymph node (PLN). The Pb+Hg and Pb+Cd combinations significantly decreased the PLN to 100 g body weight and PLN to brain weight ratio, and Pb+Hg also decreased the relative adrenal weight. After 12 weeks treatment with the same doses, effects on the thymus, kidney, and adrenal weights in the Pb+Hg, and thymus weight in the Pb+Cd, combination were seen. Pb+Cd also affected the white and red blood cell count and hematocrit. Combined with Hg or Cd, NOEL dose Pb showed toxicity, indicating that exposure limits may be inefficient in combined exposure situations.

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