This review considers analytical possibilities of Mössbauer spectroscopy in biomedical research. The results of various biomedical
applications of Mössbauer spectroscopy were grouped as quantitative and qualitative studies of biological molecules during
molecular diseases, studies of the effect of environmental factors on biological molecules, studies of metabolic processes
with Mössbauer elements, studies of dynamic properties, studies of pharmaceuticals containing Mössbauer elements. These results
demonstrate wide possibilities of Mössbauer spectroscopy in analysis of various biologically important species for obtaining
information about the molecular nature of diseases and pathological processes.
Authors:O. B. Oshtrakh, M. I. Milder, and V. A. Semionkin
An analysis of the iron state in commercial pharmaceuticals containing ferric and ferrous iron compounds, which are used for
treatment of iron deficiency, was made by Mössbauer spectroscopy. Small variations of the FeOOH cores of injectable iron-dextran
complexes were observed. The presence of ferrous impurity in iron-dextran complexes was found. Characterization of the iron
state in vitamins and dietary supplements containing ferrous compounds was made. The presence of ferrous and ferric impurities
and iron compounds that were in disagreement with compounds announced by the manufacturer was detected by Mössbauer spectroscopy.
Authors:M. I. Oshtrakh, O. B. Milder, V. A. Semionkin, L. I. Malakheeva, and P. G. Prokopenko
Characterization of iron storage proteins in liver and spleen from normal chicken and chicken with lymphoid leukemia in comparison
with human liver ferritin were considered by Mössbauer spectroscopy (preliminary results). Small differences in Mössbauer
hyperfine parameters for both normal and lymphoid leukemia chicken liver and spleen were observed. The value of quadrupole
splitting for human liver ferritin was higher than those for chicken tissues. A decrease of iron content in lymphoid leukemia
chicken tissues was also found, however, the reason of this fact (pathology or feeding) was not clear yet.