Authors:Katarzyna Michalik, Zofia Drzazga, Anna Michnik, and M. Kaszuba
and kinetic analysis of two protease inhibitors: nelfinavir mesylate and atazanavir
sulfate, were carried out to find their thermal stability. DSC curves of both
drugs showed exothermic transition. This observed process resulted in two
steps. Obtained apparent activation energy pointed at low stability of studied
protease inhibitors in water solutions.
Authors:K. Michalik, Zofia Drzazga, Anna Michnik, and M. Kaszuba
scanning calorimetry study of the thermal behavior of nevirapine and azidothymidine
in water solution was carried out. For nevirapine scan rate dependent and
irreversible endothermic peak were found. Thermal degradation of nevirapine
as well as NVP – AZT mixture is relatively well described by the model
involving only one irreversible step determined by a first-order rate constant.
The estimated kinetic constants and activation energies indicate that the
degradation process proceeds slower for nevirapine in presence of AZT ligands
than without them.